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Human Dermal Fibroblasts, Adult

Product Name

Human Dermal Fibroblasts, Adult

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Product Code

HDF-a

Cat.No

ABC-TC3029

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Derived from adult skin’s dermal layer, Human Dermal Fibroblasts, or HDFa, are instrumental in synthesizing the skin’s connective tissue matrix. These fibroblasts are pivotal players in wound healing, where they utilize Fibronectin (FN) to facilitate their migration. Beyond wound repair, they engage in intricate interactions with epidermal cells during hair development and interfollicular skin processes. Noteworthy is their pivotal role in the groundbreaking generation of induced pluripotent stem cells (iPSC) alongside synovocytes. This achievement, made possible by the “Yamanaka cocktail” containing Oct3/4, Sox2, Klf4, and c-Myc, garnered Dr. Shinya Yamanaka the 2012 Nobel Prize in recognition of its transformative impact.

 

Why choose Human Dermal Fibroblasts, Adult from AcceGen?

Human Dermal Fibroblasts, Adult (HDFa), are cryopreserved at passage one and supplied frozen, with each vial containing over 5×105 cells in 1 ml. They exhibit spindle morphology and fibronectin-specific immunofluorescence. Tested negative for various pathogens, including HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi, they offer safety assurance. HDFa can reliably expand for up to 15 population doublings under AcceGen’s specified conditions.

 

Disease

Normal

Source Organ

Dermal

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

FOR RESEARCH USE ONLY

HDFa serve as a versatile model system for investigating various facets of cell physiology and have been prominently featured in numerous research works, especially within the realms of skin biology and reprogramming studies. These fibroblasts find application in diverse areas such as pathogen response, skin aging, wound healing, gene delivery, and skin-related disorders like scleroderma. Their utility extends to research involving ECM protein analysis, collagen metabolism, cosmetics, skin therapy, and model development, encompassing an array of multidisciplinary research avenues.

Growth Conditions

37 ℃, 5% CO2

Cell Type

Fibroblast

Growth Mode

Adherent

Product Type

Dermal Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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