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INS-1 | ||||
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| Product Name | INS-1 | |||
| Price | Get Quote | |||
| Product Code | INS1 | |||
| Cat.No | ABC-TC232S | Species | Rattus Norvegicus | |
| Size/Quantity | 1 vial | |||
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description | The INS-1 cell line, derived from x-ray-induced insulinoma in rats, exhibits a high insulin content and responsiveness to glucose changes. Cultivation relies on 2-mercaptoethanol and showcases gradual proliferation (100-hour doubling time) with beta-cell-like morphology.
Why choose INS-1 from AcceGen? INS-1 cells exhibit superior viability and quality, maintained under sterile conditions with optimal incubation settings. These cells are cryopreserved using advanced techniques and undergo rigorous quality control, ensuring their reliability for various experimental applications. | |||
| Source Organ | Pancreas | |||
| Recommended Medium And Supplement | RPMI 1640 + 10% FBS | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | FOR RESEARCH USE ONLY The INS-1 cell line, renowned for its stability and preserved differentiation, serves as an ideal model to investigate diverse facets of beta-cell activity. It finds extensive utility in deciphering insulin secretion mechanisms, particularly excelling as a tool to explore glucose-triggered insulin release. Moreover, INS-1 cells offer valuable insights into the expression and regulation of proglucagon-derived peptides within primary islets, unraveling their responses to a range of metabolic stimuli.
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| Growth Conditions | 37 ℃, 5% CO2 | |||
| Cell Type | β Cell | |||
| Growth Mode | Adherent | |||
| Product Type | Rat Pancreas Cancer Cell Lines | |||
| Product Image |  | |||
Heterogeneous in nature, INS-1 cells comprise mature insulin-positive and immature bi-hormonal cells co-expressing insulin and glucagon. Bi-hormonal variants, lower in Nkx6.1 and lacking alpha cell markers, imply incomplete maturation. Prolonged glucose exposure diminishes insulin gene and protein expression, subsequently reducing insulin and proglucagon-derived peptide levels, including GLP-1, GLP-2, and glucagon.- ONLINE INQUIRY
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