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MONO-MAC-6 | ||||
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| Product Name | MONO-MAC-6 | |||
| Price | Get Quote | |||
| Product Code | MONO-MAC-6; Mono-mac-6; MONO-MAC 6; Mono Mac 6; Mono Mac6; MonoMac 6; MonoMac6; MONOMAC6; MM6 | |||
| Cat.No | ABC-TC478S | Species | Human | |
| Size/Quantity | 1 vial | |||
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description | MONO-MAC-6 is a human monocyte cell line derived from patients with acute monocytic leukemia. MONO-MAC-6 cells possess phenotypic and functional features of mature monocytes such as CD14 expression, phagocytic capacity, and cytokine production. Acute monocytic leukemia (AMoL or AML-M5) is a type of acute myeloid leukemia characterized by peripheral monocytosis. More than 80% of the nucleated cells of AMoL are of monocytic origin. Studies demonstrate that MONO-MAC-6 cells exhibit similar monocyte-endothelial interaction to human monocytes. Why choose MONO-MAC-6 from AcceGen? MONO-MAC-6 cells are established from the peripheral blood of a 64-year-old man with relapsed acute monocytic leukemia. Cells are cryopreserved to ensure the best viability. Each vial contains more than 1×10^6 cells in 1ml volume. MONO-MAC-6 cells carry a t(9;11)(p22;q23) translocation, which results in the fusion of KMT2A-MLLT3 gene (MLL-MLLT3; MLL-AF9). Subculture cells at a split ratio of 1:3 to 1:5 with a cell seeding density between 0.3×10^6 to 1×10^6 cells/ml. | |||
| Disease | Acute Monocytic Leukemia | |||
| Quality Control | All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens. | |||
| Recommended Medium And Supplement | RPMI 1640 + 10% FBS | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | For research use only MONO-MAC-6 is a useful cell model for in vitro studies of monocyte biology and physiology. They can also be used for cytogenetic analysis of gene translocation, gene expression profiling, drug screening assay and testing response towards various molecules. | |||
| Key Features | – Backed by AcceGen advanced technology – Cryopreserved for highest viability and plating efficiency – Quality-guaranteed for accurate results – Timely technical support for best experimental outcomes | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Product Type | Human Leukemia Cell Lines | |||
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