AcceGen has pioneered the development of microRNA research and diagnostics tools with leading-edge services. We’re committed to pave new ways to meet all your needs for miRNA agomir/ antagomir synthesis.
Agomir is chemically-modified double-strand miRNA mimics. Its antisense stand is modified: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group and full length nucleotide 2'-methoxy modification. Antagomir is chemically-modified single-strand miRNA inhibitor: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group and full length nucleotide 2'-methoxy modification. Antagomirs are used as a method to constitutively inhibit the activity of specific miRNAs.
AcceGen’s Antagomir and Agomir have a higher affinity for cell membrane than other common miRNA inhibitors and mimics, so the amount of transfection reagent could be drastically reduced in the cell transfection experiment. With higher stability and inhibiting effect, it is also suitable for animal in vivo RNAi experiment. These products can be easily injected into the animal by the methods of intravenous or local injection. AcceGen’s Antagomir and Agomir are good choices for long-term miRNA loss-of-function and gain-of-function studies, the interfering effect can last at least one week, even up to 5-6 weeks.
AcceGen’s microRNA agomir/antagomir synthesis service has the following advantages:
1. Cover all human, mouse and rat miRNAs listed in miRbase
2. More stable, easier to pass the cell membrane and tissue gap
3. Purified and ready-to transfect
4. Short synthesis cycle and cost efficiency