Viral Infection & Antiviral Drug Screening: The Right Cell Models for Emerging Pathogens

From ancient epidemics to modern pandemics, viral infections remain a serious global health challenge. Over centuries, scientists have made tremendous efforts to develop effective antiviral therapies and preventive strategies. The rapid development of mRNA vaccine technology—awarded the Nobel Prize for pioneering nucleoside modification technologies—has reshaped our approach to infectious diseases such as COVID-19 and RSV. Beyond these, mRNA platforms are now expanding into cancer immunotherapy and other precision medicine fields.

These advances emphasize not only the speed of biomedical innovation but also the critical importance of precisely characterized, highly permissive cell models. These models are essential for understanding viral pathogenesis, screening antiviral compounds, and developing next-generation vaccines.

Matching the Perfect Cell Model to Your Viral Research

At AcceGen, we offer a comprehensive portfolio of highly permissive cell lines and primary human cells optimized for viral pathology research, mRNA vaccine development, and antiviral drug screening. Our models support applications ranging from antigen expression to delivery system optimization and immunogenicity assessment.

Key Cell Models for Cutting-Edge Research

For high-yield antigen production & mRNA Translation Validation:

• HEK293 (Human Embryonic Kidney Cells): Exhibit exceptional transfection efficiency, these cells are a gold standard for high-titer recombinant protein production and mRNA vaccine development, including COVID-19.
• CHO-K1 (Chinese Hamster Ovary Cells): One of the favorite models for large-scale protein production of viral proteins, such as COVID-19 spike or RSV F proteins.

For lipid nanoparticles (LNPs) or other mRNA Delivery Vehicles Evaluation:

• HeLa (Human Cervical Cancer Cells): A classic model for testing cellular uptake and intracellular release of mRNA-LNP complexes, critical for HPV research and oncolytic virus studies.

For in vivo Immune Response & Vaccine Efficacy Testing:

• THP-1 (Human Monocytic Cell Line): Can be differentiable into macrophages/dendritic cells, making them ideal for cytokine profiling and immune activation studies.
• Huh7 (Human Liver Carcinoma Cells): Excellent for assessment of intracellular dynamics and mRNA vaccine induced immune activation.

For Viral Neutralization & Replication Assays:

• Vero Cells (African Green Monkey Kidney Cells): Golden standard models for viral neutralization assays, including COVID-19 vaccine efficacy testing.

Why Choose AcceGen?

Our rigorously quality-controlled cell models ensure reproducibility, high permissiveness, and physiological relevance—key factors in advancing research on emerging viruses and therapeutic innovations. Whether you're developing antiviral drugs, optimizing mRNA vaccines, or studying viral escape mechanisms, AcceGen provides the right cellular tools to accelerate your discoveries.

Join the forefront of virology and vaccine research—with the right cells, for the right breakthroughs.