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Human Renal Proximal Tubule Cells

Product Name

Human Renal Proximal Tubule Cells

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Cat.No

ABC-TC4248

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Renal proximal tubule cells (RPTCs) form single-layer epithelium that covers the basement membrane. They are responsible for the reabsorption of most solutes from the glomerular filtrate and the excretion of metabolic wastes and xenobiotics into the tubule lumen. RPTCs exhibit apicobasal polarity, which is essential for renal filtration. Renal proximal convoluted tubule epithelial cells express different enzymes in the urine and are involved in drug transportation and metabolism. RPTCs are sensitive to injury. When exposed to toxic or ischemic conditions, their death can lead to acute or chronic kidney disease.

Why choose Human Renal Proximal Tubule Cells (HRPTCs) from AcceGen?

HRPTCs are isolated from human kidneys using AcceGen’s advanced technology. Cells at passage one are cryopreserved to ensure the best viability. Each vial contains more than 5×10^5 cells in 1ml volume. HRPTCs are characterized by the expression of cytokeratin-18 and/or -19 using immunofluorescence. HRPTCs are guaranteed for further expansion of at least 15 doublings following protocols provided by AcceGen.

Disease

Normal

Source Organ

Kidney

Quality Control

All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

For research use only

Due to their significant role in renal homeostasis, human renal proximal tubule cells provide a useful tool for studying the biology and pathophysiology of renal tubular cells in vitro. They can be applied to research such as:

– HRPTCs repair mechanism after injury and their role in the progression of renal fibrosis.

–  Intercellular talk between HRPTCs and other cells.

–  High-throughput screening of drugs and toxicities.

– Role in renal diseases such as tubular necrosis, tubulointerstitial injury, nephrotoxicity, and renal cancer.

Key Features

– Backed by AcceGen advanced technology

– Cryopreserved for highest viability and plating efficiency

– Quality-guaranteed for accurate results

– Timely technical support for best experimental outcomes

Growth Conditions

37 ℃, 5% CO2

Cell Type

Tubular Cell

Growth Mode

Adherent

Product Type

Renal Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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