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Human Type II Alveolar Epithelial Cells

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Human Type-II Pulmonary Alveolar Epithelial Cells (HPAEpiC-II) provided by AcceGen have been isolated from human normal lung tissue. HPAEpiC-II are cryopreserved as primary cultures and shipped with dry ice. AcceGen also offers optimized media and reagents for the growth and in vitro maintenance of Human Type-II Pulmonary Alveolar Epithelial Cells which are quality tested together […]
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Home | Primary Cells | Human Primary Cells | Respiratory System Primary Cells | Human Type II Alveolar Epithelial Cells
Species

Human
Cat.No

ABC-TC5515
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Lung
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Pulmonary Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Description

Human Type II Alveolar Epithelial Cells are isolated from human lung tissue, playing a critical role in maintaining the alveoli integrity and function. Morphologically, these cells exhibit a cuboidal shape with apical microvilli and cytoplasmic lamellar bodies. In vitro, the cells show adherent growth. Type II Alveolar Epithelial Cells secrete cytokines such as IL-6 as well as chemokines like CXCL8. They play key roles in pulmonary surfactant production, alveolar repair, immune modulation, and fluid homeostasis. They characteristically express surfactant proteins, especially surfactant protein C (SP-C), which is essential for alveolar stability and serves as a specific marker for type II alveolar cells. Their ability to proliferate and differentiate makes them crucial for lung regeneration after injury, while dysfunction contributes to respiratory diseases such as pulmonary fibrosis, acute respiratory distress syndrome (ARDS), and COVID-19-related lung damage.

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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Yoshihiro Nakata, Hirotaka Ode, Mai Kubota, Takaaki Kasahara, Kazuhiro Matsuoka, Atsuko Sugimoto, Mayumi Imahashi, Yoshiyuki Yokomaku, Yasumasa Iwatani, Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome, Nucleic Acids Research, Volume 51, Issue 2, 25 January 2023, Pages 783–795, https://doi.org/10.1093/nar/gkac1238.

Application

  • Human Type II Alveolar Epithelial Cells can be used for mechanism exploration, drug screening and toxicity assessment of lung diseases such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD). They can also be used to evaluate the cytotoxicity and metabolic characteristics of inhaled drugs (such as glucocorticoids or antiviral drugs).

Frequently Asked Questions

  • What are Human Type II Alveolar Epithelial Cells?

    Human Type II Alveolar Epithelial Cells (AEC II) are specialized cells located in the alveoli of the lungs. They are responsible for the production and secretion of surfactant, a substance that reduces surface tension within the alveoli, preventing lung collapse. Additionally, they play a role in alveolar repair and regeneration.

  • What are the primary functions of Type II Alveolar Epithelial Cells?

    The primary functions of Type II Alveolar Epithelial Cells include:
    – Producing and secreting pulmonary surfactant to lower surface tension in the alveoli.
    – Acting as progenitor cells for the alveolar epithelium, allowing for repair and regeneration of the lung tissue.
    – Participating in the immune defense of the lungs by engulfing and processing foreign particles.

  • What are the applications of Human Type II Alveolar Epithelial Cells in research?

    Human Type II Alveolar Epithelial Cells are used in a variety of research applications, including:
    – Studying lung physiology and pathology.
    – Investigating mechanisms of lung diseases such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD).
    – Developing and testing new drugs and therapies for lung conditions.
    – Exploring cell-based therapies for lung regeneration and repair.

  • Do Type II Alveolar Epithelial Cells transdifferentiate into other cell types?

    Yes, Type II Alveolar Epithelial Cells have the capacity to transdifferentiate into Type I Alveolar Epithelial Cells. Type I cells cover a large surface area of the alveolar walls and are involved in gas exchange. This transdifferentiation is crucial for the repair and regeneration of the alveolar epithelium following lung injury.

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