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Human Pulmonary Alveolar Epithelial Cells

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AcceGen cells & cell lines
Product Name

Human Pulmonary Alveolar Epithelial Cells

Product Code

HPAEpiC

Cat.No

ABC-TC3770

Species

Human

Biosafety Level

1

Size/Quantity

1 vial

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Pulmonary alveolar epithelial cells (PAEpiC) are comprised of alveolar type I and type II epithelial cells, line more than 99% of the internal surface area of the lung. Type I cells are large squamous cells whose thin cytoplasmic extensions cover >95% of the internal surface area. They contain aquaporins and exhibit the highest osmotic water permeability of among all mammalian cells. Type II cells, which cover 2-5% of the surface area, produce, secrete, and recycle pulmonary surfactant. The currently accepted hypothesis is that Type II cells maintain pulmonary fluid homeostasis by regulating active Na+ transport in the lungs, whereas Type I cells are “inert” cells that provide solely a barrier function, rather than having active functions. Recent study indicates that Type I cells are also important in regulating ion and fluid transport. HPAEpiC from AcceGen Research Laboratories are isolated from human lung tissue. HPAEpiC are cryopreserved at primary culture and shipped with dry ice. Each vial contains >1 x 10^6 cells in 1 ml volume. HPAEpiC are characterized by immunofluorescent method with antibodies CK-18, -19, and vimentin. HPAEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HPAEpiC are guaranteed to further culture at the conditions provided by AcceGen Research Laboratories. However, this cell type is not recommended for expanding or long term cultures since the cells would differentiate into type I alveolar epithelial cells immediately after plating and type I alveolar epithelial cells do not proliferate in culture.

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Hernandez, J., Beaty, D., Fruhwirth, L., Sloan, J., Chaves, A., & Riordan, N. (2020). Dodging COVID-19 infection: Low expression and localization of Angiotensin-Converting Enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2) in Mesenchymal Stem Cells derived from human umbilical cord (hUC-MSCs). . https://doi.org/10.21203/rs.3.rs-36376/v1

Application

For research use only

Product Type

Pulmonary Cells

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