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Human Pulmonary Alveolar Epithelial Cells

Product Name

Human Pulmonary Alveolar Epithelial Cells

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1 vial

Biosafety Level


Shipping Info

Dry Ice


Liquid Nitrogen


Human Pulmonary alveolar epithelial cells (HPAEpiC), also called Human Pneumocytes, are separated from human lung tissue. Human lung alveolar epithelial cells line the alveoli and comprise of 2 subtypes of epithelial cells known as Type I Alveolar Cells (AT1) and Type II Alveolar Cells (AT2).

Type 1 vs Type 2 Pneumocytes
AT1 cells are large squamous cells that account for over 95% of the alveolar surface area, type II cells are much smaller than Type I, scattered between Type I and adjacent alveolar septal junctions. Type I pneumocytes form the epithelial component of the thin air–blood barrier, while Type II pneumocytes secrete surfactants that form a fatty film to lowering surface tension. AT2 cells can also differentiate to replace damaged AT1 cells. Type II Alveolar cells contain Na+-, K+-ATPase and amiloride-sensitive epithelial Na+ channels.

Why Choose Human Pneumocytes from AcceGen?
AcceGen provides cryopreserved primary alveolar epithelial cells for the best viability and plating efficiency. Each vial contains >0.5 x 10^6 cells in 1ml volume. AcceGen Human Pulmonary alveolar epithelial cells are characterized by immunofluorescent method with antibodies E-cadherin and ZO-1. Cells are guaranteed for future culture in our recommended Alveolar Epithelial Cell Medium.
Purified Human Type II Alveolar Epithelial Cells and Immortalized Human Alveolar Epithelial Cell Line are also available in AcceGen.



Source Organ

Pulmonary Alveolar

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Hernandez, J., Beaty, D., Fruhwirth, L., Sloan, J., Chaves, A., & Riordan, N. (2020). Dodging COVID-19 infection: Low expression and localization of Angiotensin-Converting Enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2) in Mesenchymal Stem Cells derived from human umbilical cord (hUC-MSCs). https://doi.org/10.21203/rs.3.rs-36376/v1
Cabon, L., Petropolis, D., Tien-Street, W., Ng, P.R., Grant, H.S., Karalis, K., Hamilton, G.A., Sam, J., Weinzierl, T., Fauti, T. and Freimoser-Grundschober, A., 2021. Human immunocompetent Organs-on-Chips platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies. bioRxiv.
Panigrahi, S., Goswami, T., Ferrari, B., Antonelli, C.J., Bazdar, D.A., Gilmore, H., Freeman, M.L., Lederman, M.M. and Sieg, S.F., 2021. SARS-CoV-2 Spike Protein Destabilizes Microvascular Homeostasis. Microbiology spectrum, 9(3), pp.e00735-21.


For research use only
Human Pneumocytes Applications
-Study the influences of the outside environment on the human respiratory system, by treating alveolar epithelial cells with damage factors like allergens, pollutants, irritants, infectious bacterial, or viral.
-Study the role of alveolar epithelial cells in barrier function, pathogen defense, immune function regulation, and its relationship with lung diseases.
-Assist to prove the feasibility of lung tissue regeneration induced by lung stem cells.

Key Features

-Backed by AcceGen advanced technology
-Cryopreserved at primary culture and shipped with dry ice
-Quality-tested for accurate results

Growth Conditions

37 ℃, 5% CO2

Cell Type


Growth Mode


Product Type

Pulmonary Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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