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Human Pulmonary Alveolar Epithelial Cells

Product Name

Human Pulmonary Alveolar Epithelial Cells

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Product Code

HPAEpiC

Cat.No

ABC-TC3770

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Human Pulmonary alveolar epithelial cells (HPAEpiC), also called Human Pneumocytes, are separated from human lung tissue. Human lung alveolar epithelial cells line the alveoli and comprise of 2 subtypes of epithelial cells known as Type I Alveolar Cells (AT1) and Type II Alveolar Cells (AT2).

Type 1 vs Type 2 Pneumocytes
AT1 cells are large squamous cells that account for over 95% of the alveolar surface area, type II cells are much smaller than Type I, scattered between Type I and adjacent alveolar septal junctions. Type I pneumocytes form the epithelial component of the thin air–blood barrier, while Type II pneumocytes secrete surfactants that form a fatty film to lowering surface tension. AT2 cells can also differentiate to replace damaged AT1 cells. Type II Alveolar cells contain Na+-, K+-ATPase and amiloride-sensitive epithelial Na+ channels.

Why Choose Human Pneumocytes from AcceGen?
AcceGen provides cryopreserved primary alveolar epithelial cells for the best viability and plating efficiency. Each vial contains >0.5 x 10^6 cells in 1ml volume. AcceGen Human Pulmonary alveolar epithelial cells are characterized by immunofluorescent method with antibodies E-cadherin and ZO-1. Cells are guaranteed for future culture in our recommended Alveolar Epithelial Cell Medium.
Purified Human Type II Alveolar Epithelial Cells and Immortalized Human Alveolar Epithelial Cell Line are also available in AcceGen.

Disease

Normal

Source Organ

Pulmonary Alveolar

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Recommended Medium And Supplement

ABM-TM3770 Human Pulmonary Alveolar Epithelial Cells Medium Kit

Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Hernandez, J., Beaty, D., Fruhwirth, L., Sloan, J., Chaves, A., & Riordan, N. (2020). Dodging COVID-19 infection: Low expression and localization of Angiotensin-Converting Enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2) in Mesenchymal Stem Cells derived from human umbilical cord (hUC-MSCs). https://doi.org/10.21203/rs.3.rs-36376/v1
Cabon, L., Petropolis, D., Tien-Street, W., Ng, P.R., Grant, H.S., Karalis, K., Hamilton, G.A., Sam, J., Weinzierl, T., Fauti, T. and Freimoser-Grundschober, A., 2021. Human immunocompetent Organs-on-Chips platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies. bioRxiv.
Panigrahi, S., Goswami, T., Ferrari, B., Antonelli, C.J., Bazdar, D.A., Gilmore, H., Freeman, M.L., Lederman, M.M. and Sieg, S.F., 2021. SARS-CoV-2 Spike Protein Destabilizes Microvascular Homeostasis. Microbiology spectrum, 9(3), pp.e00735-21.

Application

For research use only
Human Pneumocytes Applications
-Study the influences of the outside environment on the human respiratory system, by treating alveolar epithelial cells with damage factors like allergens, pollutants, irritants, infectious bacterial, or viral.
-Study the role of alveolar epithelial cells in barrier function, pathogen defense, immune function regulation, and its relationship with lung diseases.
-Assist to prove the feasibility of lung tissue regeneration induced by lung stem cells.

Key Features

-Backed by AcceGen advanced technology
-Cryopreserved at primary culture and shipped with dry ice
-Quality-tested for accurate results

Growth Conditions

37 ℃, 5% CO2

Cell Type

Epithelial

Growth Mode

Adherent

QuestionsthreeWhat are the primary functions of Human Pulmonary Alveolar Epithelial Cells?
Product Type

Pulmonary Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial

Frequently Asked Questions

  • What are Human Pulmonary Alveolar Epithelial Cells?

    Human Pulmonary Alveolar Epithelial Cells are specialized cells that line the alveoli in the lungs. They are crucial for gas exchange, providing a large surface area for oxygen and carbon dioxide to diffuse between the air in the lungs and the blood in the pulmonary capillaries. These cells come in two main types: Type I cells, which are involved in the gas exchange process, and Type II cells, which secrete surfactant to reduce surface tension and prevent alveolar collapse.

  • What is the differentiation capacity of Human Pulmonary Alveolar Epithelial Cells？

    Human Pulmonary Alveolar Epithelial Cells have limited differentiation capacity in comparison to stem cells. Type II alveolar epithelial cells can proliferate and differentiate into Type I alveolar epithelial cells, which are essential for gas exchange. However, they do not typically differentiate into other cell types outside the alveolar epithelium lineage. This limited differentiation potential is crucial for maintaining the specialized functions of the alveolar epithelium in gas exchange and surfactant production. In vitro studies often explore these differentiation processes to better understand lung development, repair, and response to injury.

  • What are the primary functions of Human Pulmonary Alveolar Epithelial Cells?

    The primary functions of Human Pulmonary Alveolar Epithelial Cells include:
    – Gas Exchange: Facilitating the diffusion of oxygen into the blood and carbon dioxide out of the blood.
    – Surfactant Production: Type II alveolar cells produce and secrete surfactant, a substance that reduces surface tension in the alveoli and prevents their collapse.
    – Barrier Function: Providing a physical barrier to protect against inhaled pathogens and particulates.
    – Fluid Homeostasis: Regulating the balance of fluids in the alveolar space to maintain optimal conditions for gas exchange.

  • What are the primary applications of Human Pulmonary Alveolar Epithelial Cells in research?

    Human Pulmonary Alveolar Epithelial Cells are used in a variety of research applications, including:
    – Respiratory Disease Research: Studying the mechanisms of diseases such as pulmonary fibrosis, acute respiratory distress syndrome (ARDS), and lung cancer.
    – Drug Testing and Development: Evaluating the effects of new drugs and treatments targeting lung diseases.
    – Toxicology Studies: Assessing the impact of environmental pollutants, chemicals, and other harmful substances on lung cells.
    – Infection Studies: Investigating the interactions between respiratory pathogens (e.g., viruses, bacteria) and lung epithelial cells to understand infection mechanisms and host responses.

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