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Human Schwann Cells

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Product Name

Human Schwann Cells

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Product Code

HSwC

Cat.No

ABC-TC3793

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Schwann Cells (SC), also called neurilemma cells, reside in the Peripheral Nervous System (PNS) of all vertebrate species. Human Schwann Cells (HSwC) are glial cells that keep both myelinated and unmyelinated peripheral nerve fibres alive. Human Schwann cells play an important role in supporting the development, function, and regeneration of peripheral nerves. There are two types of Schwann cells: myelinating and nonmyelinating Schwann cells. It is noteworthy that the process of Schwann Cells differentiating into myelinating or non-myelinating cells is reversible. Schwann Cells form the myelin sheath in myelinated axons. Nonmyelinating Schwann cells play a role in axon maintenance and are vital to neuronal survival.

Schwann Cells vs Oligodendrocytes
To some degree, these cells are equivalent to oligodendrocytes, a type of neuroglia in the central nervous system. However, a single myelinating Schwann Cell provides insulation to only one axon. While each oligodendrocyte can extend this process to 50 axons.

The in vitro proliferative Human Schwann Cells can be stimulated by various growth factors including PDGF, FGF, neuregulin, and others.

Why choose Human Schwann Cells from AcceGen

1 Isolated from human spinal nerve.
2 Each vial contains >5 x 10^5 cells in 1 ml volume.
3 Cryopreserved at passage one and delivered frozen
4 Characterized by immunofluorescence with antibodies specific to S100, GFAP and CD90
5 Guaranteed to further expand for 10 population doublings

Disease

Normal

Source Organ

Brain

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

For research use only
Human Schwann Cells obtained via in vitro culture are found useful for correcting the deficiencies of an injury or disease.
Human Schwann Cell model system has great potential in therapeutic genes and drugs screening, treatment for acquired and inherited demyelinating neuropathies. The HSwC from specific patient could be used to study an onset to understand mechanisms.

Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Growth Conditions

37 ℃, 5% CO2

Cell Type

Schwann Cell

Growth Mode

Adherent

Product Type

Nervous Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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