For research use only
| Cat No. | ABC-TC3793 |
| Product Type | Nervous Cells |
| Cell Type | Schwann Cell |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Peripheral Nerves |
| Disease | Normal |
| Storage | Liquid Nitrogen |
Human Schwann Cells are glial cells used to model nerve myelination, axon-glia interaction, and peripheral nerve regeneration mechanisms in vitro.
Human Schwann Cells (schwann cells) are derived from the peripheral nervous system. They are a type of glial cells and play an important role in supporting the development, function, and regeneration of peripheral nerves. These cells are able to secrete various growth factors to promote axonal growth, such as nerve growth factor, brain-derived neurotrophic factor, ciliary neurotrophic factor, neurotrophin-3, fibroblast growth factor and cerebral dopamine neurotrophic factor. Schwann cells exhibit bipolar or tripolar morphology and grow in an adherent monolayer in vitro. Following nerve injury, Schwann cells undergo phenotypic changes to create a regenerative microenvironment by clearing myelin debris, forming regeneration tracks (Büngner bands), and upregulating growth factor production. They express characteristic markers such as S100β, p75^NTR, GFAP, and myelin protein zero (MPZ). Their plasticity and regenerative capacity make them promising candidates for cell-based therapies in peripheral nerve repair and neurodegenerative diseases. Schwann cells play a crucial role in myelin sheath formation and repair, contrasting with oligodendrocytes in the central nervous system, and are essential for maintaining the integrity and function of peripheral nerves.
| Product Code | HSwC |
| Species | Human |
| Cat.No | ABC-TC3793 |
| Product Category | Primary Cells |
| Size/Quantity | 1 vial |
| Cell Type | Schwann Cell |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Peripheral Nerves |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Nervous Cells |
| Key Features | -Backed by AcceGen advanced technology |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Human Schwann Cells obtained via in vitro culture are found useful for correcting the deficiencies of an injury or disease. Human Schwann Cell model system has great potential in therapeutic genes and drugs screening, treatment for acquired and inherited demyelinating neuropathies. These cells from specific patient could be used to study an onset to understand mechanisms.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Human Schwann Cells offered are mature Schwann Cells.
Schwann cells are glial cells of the peripheral nervous system that ensheath and myelinate axons. They provide structural support, enhance nerve signal conduction, and play essential roles in peripheral nerve development and repair.
Schwann cells are located in the peripheral nervous system, where they associate with peripheral nerve fibers and form myelin sheaths or non-myelinating support structures.
Schwann cells are not stem cells, but they exhibit a degree of cellular plasticity. Under certain conditions, they can adopt progenitor-like states that contribute to nerve regeneration.
