For research use only
| Cat No. | ABC-TC3704 |
| Product Type | Nervous Cells |
| Cell Type | Microglia |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Disease | Normal |
| Storage | Liquid Nitrogen |
Human Microglia Primary Cells from CNS parenchyma support neuroinflammation, immune surveillance, and CNS disease modeling in vitro platforms.
Human Microglia cells are the resident macrophage population of the central nervous system (CNS), originating from yolk sac progenitors during embryonic development. When isolated from brain tissue and cultured in vitro, these cells exhibit adherent growth with a characteristic ramified morphology under resting conditions. As the primary immune sentinels of the CNS, quiescent microglia constantly survey their microenvironment through dynamic process motility while maintaining an immunologically silent phenotype with minimal expression of co-stimulatory molecules such as CD40 and CD86. However, upon CNS injury, infection, or in neurodegenerative conditions, microglia undergo rapid activation-transitioning to an amoeboid morphology and upregulating surface markers including CD40, CD86, MHC class II, and TREM2. Activated microglia release both pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and anti-inflammatory factors (IL-10, TGF-β), along with reactive oxygen species and proteinases that participate in pathogen defense and debris clearance. In primary microglia culture, brain microglia exhibit key functions in immune surveillance and neuroprotection, with microglial cells functioning to maintain CNS homeostasis and responding to injury or disease through their dynamic activation and signaling pathways.
| Product Code | HM |
| Species | Human |
| Cat.No | ABC-TC3704 |
| Product Category | Primary Cells |
| Size/Quantity | 1 vial |
| Cell Type | Microglia |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Nervous Cells |
| Key Features | -Backed by AcceGen advanced technology |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Human Microglia can be used to test new therapies targeting neuroinflammation. They can be used to analyze the functions of risk genes such as TREM2 and CD33 in gene editing studies. They can also be co-cultured with neurons to simulate the neural-immune interaction mechanism.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Human Microglia are a type of myeloid cell that reside in the parenchyma of the healthy central nervous system (CNS), accounting for 10 – 15% of all cells in the brain. They act as the primary active immune defense in the CNS, constantly monitoring the microenvironment and responding to noxious stimuli. Microglia play a crucial role in maintaining brain homeostasis by clearing tissue debris, damaged cells, or microbes, and scavenging for plaques, damaged neurons, and infectious agents.
When programmed cell death occurs or the CNS is injured, microglia act as brain macrophages to clear tissue debris, damaged cells, or microbes. They are highly sensitive to pathological changes and work to regulate brain homeostasis during development and in adult brains, both under physiological and pathological conditions.
Human Microglia from AcceGen are characterized by immunofluorescence with antibodies to several markers, including CD11b (Mac-1), CD68, CD86 (B7-2), HLA-ABC, HLA-DR, and RCA-1 lectin. These markers help in identifying and confirming the presence and purity of microglial cells.
Human Microglia are widely used in research because they play a vital role in the immune defense of the CNS and are involved in clearing debris and pathogens. They are also essential for studying the regulation of brain homeostasis, both during development and in adult brains, under normal and pathological conditions. This makes them valuable for understanding neurological diseases and developing potential treatments.
Researchers choose Human Microglia from AcceGen because these cells are characterized by specific immunofluorescence markers, ensuring high quality and purity. AcceGen provides reliable and well-characterized microglial cells that are essential for accurate and effective research in neuroscience and immunology.
Microglial cells are the resident immune cells of the central nervous system. They function as macrophage-like cells that monitor the neural environment and respond to injury or infection.
