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Human Microglia

Product Name

Human Microglia

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Product Code

HM

Cat.No

ABC-TC3704

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Microglia are a type of unique myeloid cells, reside in the parenchyma of the healthy central nervous system (CNS), account for 10–15% of all cells found within the brain. Microglia act as the first and main form of active immune defense in the CNS, constantly monitoring the microenvironment, in order to timely respond to different noxious stimuli (effector function). Microglia can express antigens in the context of MHC class II to CD-4 positive T cells.
Microglia Function
Under some circumstances, such as programmed cell death occurs or CNS is injured, microglia will work as brain macrophages to clear tissue debris, damaged cells, or microbes. Besides, microglial cells are also scavenging the CNS for plaques, damaged or unnecessary neurons and synapses, and infectious agents constantly, the processes of which are potentially dangerous. Therefore, microglia are extremely sensitive to pathological changes. These activities are important in the regulation of brain homeostasis during development and in the adult brain, both in physiological and pathology conditions.
Why Choose Human Microglia from AcceGen?
Human Microglia are characterized by immunofluorescence with antibodies to CD11b (Mac-1), CD68, CD86 (B7-2), HLA-ABC, HLA-DR, and RCA-1 lectin.

Disease

Normal

Source Organ

Brain

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Recommended Medium And Supplement

ABM-TM3704 Human Microglia Medium Kit

Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

For research use only
Chronic microglial activation is generally considered as a pathogenic mechanism common to several neurological disorders. Thus, microglia cells and Immortalized Human Microglia (ABI-TC4171) have become ideal model for physiopathology research on diseases like multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, dementia, etc.

Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Growth Conditions

37 ℃, 5% CO2

Cell Type

Microglia

Growth Mode

Adherent

QuestionsthreeWhat markers are used to characterize Human Microglia?
Product Type

Nervous Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial

Frequently Asked Questions

  • What are Human Microglia and their role in the central nervous system (CNS)?

    Human Microglia are a type of myeloid cell that reside in the parenchyma of the healthy central nervous system (CNS), accounting for 10 – 15% of all cells in the brain. They act as the primary active immune defense in the CNS, constantly monitoring the microenvironment and responding to noxious stimuli. Microglia play a crucial role in maintaining brain homeostasis by clearing tissue debris, damaged cells, or microbes, and scavenging for plaques, damaged neurons, and infectious agents.

  • How do Microglia respond to CNS injury or programmed cell death?

    When programmed cell death occurs or the CNS is injured, microglia act as brain macrophages to clear tissue debris, damaged cells, or microbes. They are highly sensitive to pathological changes and work to regulate brain homeostasis during development and in adult brains, both under physiological and pathological conditions.

  • What markers are used to characterize Human Microglia?

    Human Microglia from AcceGen are characterized by immunofluorescence with antibodies to several markers, including CD11b (Mac-1), CD68, CD86 (B7-2), HLA-ABC, HLA-DR, and RCA-1 lectin. These markers help in identifying and confirming the presence and purity of microglial cells.

  • Are Human Microglia useful in research?

    Human Microglia are widely used in research because they play a vital role in the immune defense of the CNS and are involved in clearing debris and pathogens. They are also essential for studying the regulation of brain homeostasis, both during development and in adult brains, under normal and pathological conditions. This makes them valuable for understanding neurological diseases and developing potential treatments.

  • Why choose Human Microglia from AcceGen?

    Researchers choose Human Microglia from AcceGen because these cells are characterized by specific immunofluorescence markers, ensuring high quality and purity. AcceGen provides reliable and well-characterized microglial cells that are essential for accurate and effective research in neuroscience and immunology.

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