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Home > Products > Immortalized Cell Lines >

Immortalized Mouse Kupffer Cell Line (ImKC)

Product Name

Immortalized Mouse Kupffer Cell Line (ImKC)

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Cat.No

ABI-TC192D

Species

Mouse

Size/Quantity

1 vial

Biosafety Level

2

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Immortalised Mouse Kupffer Cells (ImKC) are isolated from male H-2Kb-tsA58 transgenic mice which expresses the thermolabile mutant tsA58 of SV40 40 large T antigen and were sorted through identifying the F4/80 marker. The Immortalised cells expresses p53 levels with increases telomerase activity and retains the some functional features compared to the primary cells. ImKC cells can propagate without the presence of IFNy at 37°C, and are able to produce proinflammatory cytokines when induced with lipopolysaccharide (LPS). These cells are valuable for studies in proinflammatory cytokines (TNF-α, IL-6 and IL-1β) and their roles in Kuppfer cells, in processes in liver injury, and for research in chronic diseases.

Quality Control

1) Flow cytometry utilized to analyze cell surface markers F4/80, CD11b, CD14, and TLR4; 2) Western blot analysis on p53 expression; 3) qRT-PCR used to analyze level of LPS induced cytokine production

Growth Properties

Adherent

Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

For research use only

Morphology

Macrophage-like

Immortalization Method

Isolated from transgenic mice expressing thermolabile mutant tsA58 of SV40 40 large T antigen

Product Type

Immortalized Cell Line

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