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Human Kupffer Cells

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Product Name

Human Kupffer Cells

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Cat.No

ABC-TC4369

Species

Human

Size/Quantity

1 vial

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Isolated and enriched from dissociated human liver tissue, Human Kupffer cells (HKC) are the resident macrophages in human liver. Kupffer cells are the densest innate liver immune cells and the first line of defense against bacteria and toxins in the intestine. Liver Kupffer cells have typical macrophages abilities like modulating hepatic inflammation and injury. Activated hepatic Kupffer cells could release inflammatory cytokines, growth factors and reactive oxygen species.
In vivo, the activation of Kupffer cells could mediate inflammation that develop into liver diseases such as Non-Alcoholic Fatty Liver Disease (NAFLD), Non-Alcoholic Steatohepatitis (NASH), and liver damage associated with certain bioactivated chemicals.

Why Choose Human Kupffer Cells from AcceGen?
AcceGen cryopreserves our Human Kupffer Cells for about 5 x 10^5 cells/vial after isolation, without being cultured.

Disease

Normal

Source Organ

Liver

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Recommended Medium And Supplement
Citation Guide

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Application

For research use only
Kupffer Cells Applications
Co-culturing with other cells to mimic lacking in vitro models for analyzing immune-mediated drug-induced hepatotoxicity
In vitro drug metabolism and pharmacokinetics (DMPK) assays
Investigation of cytokine releases that response to inflammation
Chronic liver injury research
Human Kupffer Cells are proved to be inducible with lipopolysaccharide (LPS) with the evaluation. Human Kupffer Cells also keep high activation potential.

Key Features

Backed by AcceGen advanced technology
Ship cryopreserved cells in dry ice
Quality-tested for accurate results

Growth Conditions

37 ℃, 5% CO2

Cell Type

Kupffer Cell

Growth Mode

Adherent

Product Type

Hepatic Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial

Frequently Asked Questions

  • What are Kupffer cells?

    Kupffer cells are specialized macrophages located in the liver. They are part of the mononuclear phagocyte system and play a critical role in the body’s immune response by clearing pathogens, debris, and aged red blood cells from the blood.

  • What is the primary function of Kupffer cells?

    The primary function of Kupffer cells is to act as scavengers in the liver, engulfing and digesting cellular debris, pathogens, and other particles through phagocytosis. They also produce cytokines and other molecules that modulate immune responses and inflammation.

  • How to isolate Kupffer cells from liver?

    Kupffer cells are typically isolated from liver tissue through a process that involves enzymatic digestion of the liver, followed by density gradient centrifugation or magnetic sorting to separate them from other liver cell types.

  • What roles do Kupffer cells play in liver homeostasis and metabolism?

    Kupffer cells contribute to liver homeostasis by clearing pathogens and debris, regulating immune responses, and producing cytokines that maintain the balance of liver cell functions. They also play a role in the metabolism of lipids and iron.

  • How do Kupffer cells interact with other cells in the liver?

    Kupffer cells interact with hepatocytes, stellate cells, endothelial cells, and infiltrating immune cells through direct cell-to-cell contact and the secretion of signaling molecules. These interactions help coordinate immune responses and maintain liver function.

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