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Human Kupffer Cells

Product Name

Human Kupffer Cells

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Cat.No

ABC-TC4369

Species

Human

Size/Quantity

1 vial

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Isolated and enriched from dissociated human liver tissue, Human Kupffer cells (HKC) are the resident macrophages in human liver. Kupffer cells are the densest innate liver immune cells and the first line of defense against bacteria and toxins in the intestine. Liver Kupffer cells have typical macrophages abilities like modulating hepatic inflammation and injury. Activated hepatic Kupffer cells could release inflammatory cytokines, growth factors and reactive oxygen species.
In vivo, the activation of Kupffer cells could mediate inflammation that develop into liver diseases such as Non-Alcoholic Fatty Liver Disease (NAFLD), Non-Alcoholic Steatohepatitis (NASH), and liver damage associated with certain bioactivated chemicals.

Why Choose Human Kupffer Cells from AcceGen?
AcceGen cryopreserves our Human Kupffer Cells for about 5 x 10^5 cells/vial after isolation, without being cultured.

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

For research use only
Kupffer Cells Applications
Co-culturing with other cells to mimic lacking in vitro models for analyzing immune-mediated drug-induced hepatotoxicity
In vitro drug metabolism and pharmacokinetics (DMPK) assays
Investigation of cytokine releases that response to inflammation
Chronic liver injury research
Human Kupffer Cells are proved to be inducible with lipopolysaccharide (LPS) with the evaluation. Human Kupffer Cells also keep high activation potential.

Key Features

Backed by AcceGen advanced technology
Ship cryopreserved cells in dry ice
Quality-tested for accurate results

Product Type

Hepatic Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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