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| Species | Human |
| Cat.No | ABC-TC4369 |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
| Product Category | Primary Cells |
| Size/Quantity | 1 vial |
| Cell Type | Kupffer Cell |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Liver |
| Disease | Normal |
| Storage | Liquid Nitrogen |
| Product Type | Hepatic Cells |
| Key Features | Backed by AcceGen advanced technology |
Human Kupffer Cells are isolated from human liver tissue. Kupffer cells are liver-resident macrophages, residing within the sinusoidal lumen. These cells contain endocytic vesicles and abundant lysosomes, and can express several endocytic lectin receptors like C-type lectin receptor CLEC4F, which plays a crucial role in mediating platelet destruction. Kupffer cells possess self-renewal capacity and perform key roles in phagocytosis, immune surveillance, and clearance of bacteria as well as apoptotic or necrotic hepatocytes. Studies have shown that Kupffer cells are implicated in different types of liver damage, such as copper and iron toxicity, alcoholic liver disease, and non-alcoholic fatty liver disease.In addition to CLEC4F, they express classical macrophage surface markers including CD68, CD14, CD163, and F4/80, confirming their identity and phagocytic capability.
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Human Kupffer Cells can be used to study liver immune defense and disease mechanisms. These cells can also be used to study the immune pathological mechanisms of diseases such as non-alcoholic fatty liver disease (NAFLD) and drug-induced liver injury.
Kupffer cells are specialized macrophages located in the liver. They are part of the mononuclear phagocyte system and play a critical role in the body’s immune response by clearing pathogens, debris, and aged red blood cells from the blood.
The primary function of Kupffer cells is to act as scavengers in the liver, engulfing and digesting cellular debris, pathogens, and other particles through phagocytosis. They also produce cytokines and other molecules that modulate immune responses and inflammation.
Kupffer cells are typically isolated from liver tissue through a process that involves enzymatic digestion of the liver, followed by density gradient centrifugation or magnetic sorting to separate them from other liver cell types.
Kupffer cells contribute to liver homeostasis by clearing pathogens and debris, regulating immune responses, and producing cytokines that maintain the balance of liver cell functions. They also play a role in the metabolism of lipids and iron.
Kupffer cells interact with hepatocytes, stellate cells, endothelial cells, and infiltrating immune cells through direct cell-to-cell contact and the secretion of signaling molecules. These interactions help coordinate immune responses and maintain liver function.
