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Human Alveolar Macrophages

Product Name

Human Alveolar Macrophages

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Cat.No

ABC-H0034X

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Human Alveolar Macrophages are terminally differentiated macrophages that reside in the lung parenchyma. They are mononuclear phagocytes that guard the alveolar-blood barrier and are responsible for scavenging particles, pollutants, and invading pathogens from the airway. When encountered with viruses or large particles, alveolar macrophages (AMs) can secrete cytokines and chemokines to initiate the inflammatory process and recruit neutrophils. They also phagocytose apoptotic and necrotic cells. Altered macrophage activity has been implicated in respiratory infections and allergic lung diseases such as allergic asthma, chronic obstructive pulmonary disorder (COPD) and pulmonary alveolar proteinosis (PAP).

Why choose Human Alveolar Macrophages from AcceGen?

Human Alveolar Macrophages are derived from healthy human lungs with fully consented donors using AcceGen’s advanced technology. Cells are immediately cryopreserved to ensure the best viability. Each vial contains more than 5×10^5 cells in 1ml volume. Human alveolar macrophages are positive for CD68 or MAC387 by immunofluorescence staining.

Disease

Normal/Non-Small Cell Lung Cancer

Source Organ

Alveolar

Quality Control

All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Laurent, Paôline et al. “Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19.” Science immunology vol. 7,75 (2022): eadd4906. doi:10.1126/sciimmunol.add4906

Application

For research use only

Human Alveolar Macrophages provide an ideal cell source for studying the physiology and pathophysiology of alveolar macrophages. They can help understand the function and ontology of lung macrophages and may provide novel insight into therapeutic targets for lung disease.

Key Features

– Backed by AcceGen advanced technology

– Cryopreserved for highest viability and plating efficiency

– Quality-guaranteed for accurate results

– Timely technical support for best experimental outcomes

Growth Conditions

37 ℃, 5% CO2

Cell Type

Macrophage

Growth Mode

Adherent

Product Type

Pulmonary Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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