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Rat Liver Kupffer Cells

Product Name

Rat Liver Kupffer Cells

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Cat.No

ABC-HP030X

Species

Sprague-Dawley Rat

Size/Quantity

1 vial

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Rat Liver Kupffer Cells, isolated from healthy rat liver, are crucial sentinel cells in the liver’s immune defense system. These specialized macrophages constitute 31% of the sinusoidal cells and are strategically distributed within liver lobules, with 43% in the periportal, 28% in the midzonal, and 29% in the central areas. Kupffer cells exhibit remarkable longevity and self-renewal capabilities under physiological conditions. They serve a pivotal role in safeguarding the liver by recognizing and responding to pathogens and metastatic cells, all while maintaining tolerance to harmless self and foreign antigens. Additionally, these cells are central players in liver-related pathologies, including fibrosis, inflammation, alcoholic liver disease, fatty liver disease, and liver transplantation, contributing significantly to liver health and disease management.

 

Why choose Rat Liver Kupffer Cell from AcceGen?

AcceGen’s Rat Liver Kupffer Cells are a highly reliable research resource, with each vial containing over 1 million viable cells. These cells are guaranteed to successfully culture under the specified conditions outlined in the technical sheet. They have been rigorously tested and confirmed to be negative for mycoplasma using a PCR-based assay, and their identity has been authenticated through STR profile analysis, ensuring their purity and quality for experimental use.

Disease

Normal

Source Organ

Liver

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

FOR RESEARCH USE ONLY

Rat Liver Kupffer Cells offer a vital resource for exploring the intricate aspects of liver function and disease, both in a physiological and pathophysiological context. Their utility extends to evaluating the activation of Kupffer cells, particularly in the preclinical development of new biological entities and immunomodulators, reflecting a growing concept in drug development. Moreover, incorporating Kupffer cells into co-cultures or three-dimensional systems alongside hepatocytes can enhance the realism and predictive value of these models by simulating liver structure and function more akin to in vivo conditions, making them invaluable tools for studying drug metabolism and related research.

Growth Conditions

37 ℃, 5% CO2

Cell Type

Kupffer Cell

Growth Mode

Adherent

Product Type

Rat Primary Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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