MKN-1; MKN 1
MKN-1 is a human gastric adenosquamous carcinoma cell line derived from the metastatic site at the lymph node. MKN-1 has a point mutation amino acid replacements at exon5 of the p53. In 2023, there are about 26500 new cases of gastric cancer and 11130 deaths from this type of cancer in the USA. In all newly diagnosed cancer cases, gastric cancer is about 1.5%. Although gastric adenosquamous carcinoma is a rare type of gastric cancer with less than 1% incidence, it presents a more aggressiveness and serious prognosis compared with other types of gastric cancer.
Why choose MKN-1 from AcceGen?
Accegen offers every customer MKN-1 with the best quality and viability. The production of MKN-1 is conducted using standardized culture system and procedures. Before delivery, MKN-1 passes rigorous tests, including the parameters assessing cell morphology and viability, and negative performance for mycoplasma, bacteria, yeast, and fungi.
|Recommended Medium And Supplement
RPMI 1640 + 10% FBS
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FOR RESEARCH USE ONLY
Due to the rarity of human gastric adenosquamous carcinoma, limited clinical options are available to these patients. The utilization of MKN-1 in the scientific reports might unravel the cell proliferative properties of gastric carcinomas. MKN-1 uncovered that E-cadherin can be silenced by promoter CpG hypermethylation. MKN-1 can also used to discover inhibitory effects on tumor invasion. For example, eupatilin and exogenous RUNX3 has the potential to inhibit gastric cancer cell proliferation in MKN-1.
37 ℃, 5% CO2
Human Gastric Cancer Cell Lines
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