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Immortalized Cell Lines

Immortalized Human Hepatocytes

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The cell line was prepared by immortalizing hepatocytes from a 12 year-old Caucasian female donor with the SV40 large T antigen. The donor tested negative for CMV, HIV, HBV, and HCV.
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Home | Immortalized Cell Lines | Immortalized Human Hepatocytes
Species

Human
Cat.No

ABI-TC3500
Product Category Immortalized Cell Lines
Size/Quantity

1 vial
Cell Type

Hepatocyte
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Immortalized Cell Line

Description

Immortalized Human Hepatocytes
Immortalized human hepatocytes are a human liver-derived cell line that was originally established by transducing normal human hepatocytes with the simian virus 40 (SV40) large T-antigen. these cells exhibit adherent growth properties. They retain several hepatocyte-specific functions such as albumin secretion and cytochrome P450 enzyme expression—though at reduced levels compared to primary hepatocytes.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • Immortalized hepatocytes simulate primary liver cell functions, making them invaluable in hepatology. They are employed in studies of liver disease mechanisms, drug metabolism, hepatotoxicity testing, and virus-host interactions—especially hepatitis. These cells support functional assays and disease modeling, and they are increasingly explored for cell-based therapies targeting liver failure or injury.

Frequently Asked Questions

  • What are immortalized human hepatocytes?

    Immortalized human hepatocytes are liver cells that have been genetically modified to proliferate indefinitely. This is typically achieved by introducing specific genes or using viral vectors that prevent the cells from undergoing senescence, thereby allowing continuous cell division and growth. These cells retain many of the functional characteristics of primary hepatocytes, making them valuable for research and therapeutic purposes.

  • How are immortalized human hepatocytes used in research?

    Immortalized human hepatocytes are used extensively in research to study liver function, drug metabolism, and toxicity. They provide a stable and consistent model for investigating hepatic diseases, including hepatitis and liver cancer.

  • What are the benefits of using immortalized human hepatocytes?

    Prolonged Lifespan: They can be cultured for extended periods, providing a consistent and renewable cell source.

    Liver-Specific Functions: They retain many characteristics of primary hepatocytes, such as enzyme activity related to drug metabolism.

    Reproducibility: Their continuous growth allows for reproducible experiments and large-scale studies.

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