MKN-45; MKN 45
MKN-45 is a human gastric cancer cell line derived from poorly differentiated gastric adenocarcinoma. MKN-45 cells have been used extensively in gastric cancer development study and therapeutic agent assessment. MKN-45 gastric cancer cells express wild-type p53 and are characterized by homozygous deletion of p16CDKN2/MTS1/INK4A and p15MTS2, as well as amplification of c-met oncogene and promoter mutation of E-cadherin. MKN-45 cells exhibit both normal and metaplastic gastric mucosa phenotype with preserved differentiation capacity.
Why choose MKN-45 from AcceGen?
MKN-45 is derived from poorly differentiated gastric adenocarcinoma of a 62-year-old woman. Cells are cryopreserved to ensure the best viability. Each vial contains more than 1×10^6 cells in 1ml volume. MKN-45 cells are characterized by spindle-shaped or oval-shaped morphology and present a hypertriploid karyotype with 8% polyploidy. Subculture cells at a split ratio of 1:3 to 1:5 every 5-10 days using trypsin/EDTA.
All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.
|Recommended Medium And Supplement||
RPMI 1640 + 10% FBS
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For research use only
MKN-45 cells provide a useful model for studying the biology and characteristic of gastric cancer. They can also be used to screen for potential drugs or underlying mechanism of gastric cancer and the immunological pathway associated with it.
– Backed by AcceGen advanced technology
– Cryopreserved for highest viability and plating efficiency
– Quality-guaranteed for accurate results
– Timely technical support for best experimental outcomes
37 ℃, 5% CO2
Human Gastric Cancer Cell Lines
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