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MH-S

Product Name

MH-S

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Cat.No

ABI-TC4178

Species

Mouse

Size/Quantity

1 vial

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

The MH-S cell line represents a continuous culture of murine alveolar macrophages (AM), initially derived from bronchoalveolar lavage cells of Balb/cJ mice via transformation with simian virus 40 (SV40). Characterized by their adhesion properties, lack of contact inhibition, and trypsin sensitivity, MH-S cells exhibit distinctive features. They express intracellular T-antigen and manifest DNA synthesis through the incorporation of 3H-thymidine, boasting a doubling time of approximately 48 hours, resulting in a doubling of cell numbers within 96 hours. MH-S cells maintain typical macrophage morphology, with over 98% esterase-positive cells, while being negative for peroxidase. They further express cell surface Ia and Mac-1 antigens and exhibit Fc receptor positivity, demonstrated by their capacity for rosette formation and phagocytosis of antibody-coated sheep erythrocytes. Importantly, akin to freshly isolated AM, MH-S cells display the ability to dose-dependently suppress the in vitro plaque-forming cell (PFC) response when co-cultured with splenic lymphocytes.

 

Why choose MH-S from AcceGen?

The MH-S cell line boasts exceptional features, including high viability and quality, meticulously maintained under optimal incubation conditions, cryopreserved by proficient operators, and delivered in a sterile state. Rigorous quality control ensures their accuracy and utility, making them a reliable choice for diverse research applications.

Disease

Normal

Source Organ

Alveolus

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

FOR RESEARCH USE ONLY

The MH-S cell line, characterized by its preservation of typical alveolar macrophage morphology, holds substantial promise for applications in immunology research. This cell line is particularly valuable in investigations requiring homogeneous populations of alveolar macrophages. It provides a robust platform for elucidating the immunological functions of alveolar macrophages and their potential contributions to lung pathology, offering a critical tool for advancing our understanding of lung-related diseases and immune responses in this context.

Growth Conditions

37 ℃, 5% CO2

Cell Type

Macrophage

Growth Mode

Adherent

Product Type

Immortalized Cell Lines

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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