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Primary Cells

Human Renal Interstitial Fibroblasts

  • For research use only

Cat No.

ABC-TC095L
Product Type

Renal Cells
Cell Type

Fibroblast
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Kidney
Disease

Normal
Storage

Liquid Nitrogen

Human renal interstitial fibroblasts regulate renin in anemia and BP changes, serving as models for kidney injury; handle freeze-thaw carefully.

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  • Human Renal Interstitial Fibroblasts
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Home | Primary Cells | Human Primary Cells | Urinary System Primary Cells | Human Renal Interstitial Fibroblasts

Description

Human Retinal Müller Cells are specialized glial cells isolated from adult human retinal tissue and cryopreserved after primary culture. These cells exhibit elongated, radial morphology spanning the retinal layers and express characteristic markers such as glutamine synthetase, vimentin, and CRALBP. As the principal glial cells of the retina, Müller cells provide structural and metabolic support to retinal neurons, maintain homeostasis, regulate extracellular ion balance, clear neurotransmitters, and contribute to the integrity of the blood-retinal barrier. They are critically involved in the pathophysiology of retinal diseases including diabetic retinopathy, retinal detachment, and age-related macular degeneration (AMD). Human Müller cells serve as essential models for studying retinal disorders such as diabetic retinopathy, glaucoma, and AMD. To preserve their viability and functional properties, repeated freeze-thaw cycles should be avoided during culture.

Product Code

Human Renal Interstitial Fibroblasts, Human Kidney Interstitial Fibroblasts, Primary Renal Stromal Fibroblasts, Human Nephric Interstitial Cells, Renal Connective Tissue Cells Human
Species

Human
Cat.No

ABC-TC095L
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Kidney
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Renal Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Renal Interstitial Fibroblasts serve as an essential model for investigating the cellular and molecular mechanisms underlying renal fibrosis and chronic kidney disease. They are used in drug screening to identify anti-fibrotic compounds, analysis of fibroblast activation pathways (e.g., TGF-β signaling), and studies of extracellular matrix production and remodeling. Co-culture with tubular epithelial cells and immune cells helps elucidate cell–cell interactions in the renal microenvironment. These fibroblasts are also valuable for genetic manipulation and high-throughput screening in nephrology research.

Citation

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Frequently Asked Questions

  • What are Human Renal Interstitial Fibroblasts?

    Human Renal Interstitial Fibroblasts are specialized fibroblast cells located in the interstitial space of the kidneys. They play a key role in maintaining the structural integrity of kidney tissue and are involved in the production of extracellular matrix proteins, which provide support to renal cells and blood vessels.

  • What are the primary functions of Human Renal Interstitial Fibroblasts?

    The primary functions of these fibroblasts include the production of extracellular matrix components like collagen and fibronectin, which help maintain kidney structure. Additionally, they play a crucial role in wound healing, fibrosis, and tissue remodeling, especially during kidney injury or chronic kidney disease.

  • What role do Human Renal Interstitial Fibroblasts play in kidney fibrosis?

    During kidney injury or chronic disease, Renal Interstitial Fibroblasts become activated and transform into myofibroblasts, which are involved in the overproduction of extracellular matrix. This leads to fibrosis, or scarring, which can impair kidney function over time.

  • What are Human Renal Interstitial Fibroblasts used for in research?

    These cells are used in studies related to kidney fibrosis, chronic kidney disease, tissue engineering, and drug discovery. They are essential for understanding the mechanisms behind renal fibrosis and developing treatments that target fibrotic processes in the kidney.

  • Are there specific markers used to identify Human Renal Interstitial Fibroblasts?

    Yes, Human Renal Interstitial Fibroblasts express specific markers, including vimentin, fibronectin, and α-smooth muscle actin (α-SMA) when activated. These markers help distinguish them from other cell types in the kidney, particularly when studying fibrosis and tissue remodeling.

  • What is the interstitium in the kidney?

    The renal interstitium is the connective tissue space located between renal tubules and blood vessels in the kidney. It provides structural support and contains fibroblasts, immune cells, and extracellular matrix components that regulate tissue homeostasis and fibrosis.

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