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Human Glomerular Microvascular Endothelial Cells

Product Name

Human Glomerular Microvascular Endothelial Cells

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Cat.No

ABC-TC3631

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Human glomerular microvascular endothelial cells (HGMECs) cover the luminal surface of glomerular capillaries and function to regulate vasomotor tone, blood hemostasis, and filtration of leukocytes. Glomerular endothelial cells are usually flattened and have characteristic 50-100 nm fenestrae which contribute to the permeability of the glomerular filtration barrier. HGMECs express bioactive molecules to modulate local milieu and to cross-talk with other glomerular cells, including vasoactive factors, thrombotic regulators and inflammatory modulators. Due to its vital role in blood filtration, dysfunction of the HGMECs is closely associated with pre-eclampsia, thrombotic microangiopathies, diabetic nephropathy, proteinuria, and glomerulosclerosis.

Why choose Human Glomerular Microvascular Endothelial Cells from AcceGen?

HGMECs are isolated from human kidneys using AcceGen’s advanced technology. Cells at passage one are cryopreserved with each vial contains more than 5×10^5 cells in 1ml volume. HGMECs are tested for expression of endothelial specific markers vWF/Factor VIII and/or  CD31 using immunofluorescence. HGMECs are guaranteed for further expansion of 5 populations following protocols provided by AcceGen.

Quality Control

All cell lots are tested negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi and other pathogens.

Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

For research use only

Human Glomerular Microvascular Endothelial Cells Application

HGMECs provide an ideal cell culture model for studying the function and pathophysiology of normal human glomerular endothelial cells in vitro. Co-culturing of HGMECs with podocytes and mesangial cells can be useful in exploring the cross-talk between glomerular cells. Considering their vital role in glomerular homeostasis, HGMECs can be potential  research target for developing future therapeutic interventions for chronic kidney disease or restoration of filtration capability after injury.

Key Features

– Backed by AcceGen advanced technology

– Cryopreserved for highest viability and plating efficiency

– Quality-guaranteed for accurate results

– Timely technical support for best experimental outcomes

Product Type

Renal Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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