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BV-2 Cells Derivation and biomarker
BV-2 is a type of microglial cell derived from C57/BL6 murine. The BV2 cells are immortalized by v-raf/v-myc carrying J2 retrovirus. BV2 express nuclear v-myc and the cytoplasmic v-raf oncogene products as well as the env gp70 antigen at the surface level. BV2 microglia cell line retains microglia morphological and functional characteristics. In accordance with v-raf/v-myc expressed characters, the metabolic and proliferation rate of in vitro BV-2 greatly exceeds that of other microglia.

Why Choose BV-2 from AcceGen?
AcceGen BV-2 cells are positive for MAC1 and MAC2 antigens, negative for MAC3, glial fibrillary acidic protein (GFAP) and galactocerebroside (GC).

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Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Hagan, N., Kane, J.L., Grover, D., Woodworth, L., Madore, C., Saleh, J., Sancho, J., Liu, J., Li, Y., Proto, J. and Zelic, M., 2020. CSF1R signaling is a regulator of pathogenesis in progressive MS. Cell death & disease, 11(10), pp.1-25.
Lee, H.J., Seo, M., Baek, M., Shin, Y.P., Lee, J.H., Kim, I.W., Hwang, J.S. and Kim, M., 2020. Inhibitory Effect of Protaetiamycine 6 on Neuroinflammation in LPS-stimulated BV-2 Microglia. Journal of Life Science, 30(12), pp.1078-1084.
Inada, M., Xu, H., Takeuchi, M., Ito, M. and Chen, M., 2021. Microglia increase tight-junction permeability in coordination with Müller cells under hypoxic condition in an in vitro model of inner blood-retinal barrier. Experimental Eye Research, 205, p.108490.
Liu, Y., Hammel, G., Shi, M., Cheng, Z., Zivkovic, S., Wang, X., Xu, P., He, X., Guo, B., Ren, Y. and Zuo, L., 2021. Myelin debris stimulates NG2/CSPG4 expression in bone marrow-derived macrophages in the injured spinal cord. Frontiers in Cellular Neuroscience, 15, p.80.
Li, J., Cheng, X., Fu, D., Liang, Y., Chen, C., Deng, W. and He, L., 2022. Autophagy of Spinal Microglia Affects the Activation of Microglia through the PI3K/AKT/mTOR Signaling Pathway. Neuroscience, 482, pp.77-86.

Martin, N. P., & Harry, G. J. (2022). Imaging inflammasome activation in microgliaCurrent Protocols2, e578. doi: 10.1002/cpz1.578.
Lee, J.H., Ji, S.H., Lim, J.S. et al. Anti-neuroinflammatory Effects and Brain Pharmacokinetic Properties of Selonsertib, an Apoptosis signal-regulating Kinase 1 Inhibitor, in mice. Neurochem Res 47, 3829–3837 (2022). https://doi.org/10.1007/s11064-022-03777-9.

Hasriadi et al. “Antinociceptive efficacy of Clerodendrum petasites S. Moore, a Thai medicinal plant, and its CNS safety profiles.” Journal of traditional and complementary medicine vol. 13,1 81-92. 12 Nov. 2022, doi:10.1016/j.jtcme.2022.11.001.

Lim, Jae Sung, et al. “In Vitro Anti-Inflammatory Effects of Symplocos Sumuntia Buch.-Ham. Ex D. Don Extract via Blockage of the NF-ΚB/JNK Signaling Pathways in LPS-Activated Microglial Cells.” Plants, vol. 11, no. 22, Nov. 2022, p. 3095. Crossref, https://doi.org/10.3390/plants11223095.

Janpaijit, Sakawrat et al. “Anti-neuroinflammatory effects of Cleistocalyx nervosum var. paniala berry-seed extract in BV-2 microglial cells via inhibition of MAPKs/NF-κB signaling pathway.” Heliyon vol. 8,11 e11869. 28 Nov. 2022, doi:10.1016/j.heliyon.2022.e11869.


For research use only
BV-2 Cells Application and example model
In the central nervous systems (CNS), microglial cells are resident macrophages. BV-2 shares properties with body macrophages with respect to the antigen profile, their phagocytic capacity and antimicrobial activity. Like other microglia, BV-2 can be activated to release pro-inflammatory cytokines by oxidative stress or inflammatory factors. Such stimulus possibly triggers neurodegenerative disorder such as Alzheimer and Parkinson disease, thus BV-2 is widely used as an alternative model system for primary microglia and neurodegenerative disease model in vitro. The model is usually induced by Lipopolysaccharide (LPS) treatment.

Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Growth Conditions

37 ℃, 5% CO2

Cell Type


Product Type

Mouse Brain Cancer Cell Lines

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AcceGen Frozen Cells & Cell Lines

AcceGen product bv-2 cell line

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Reviews of BV-2
AcceGen is always trying to do right by our customers and working hard to build a higher quality product.

One thought on “BV-2

Date: 10-20-2022 15:38:03

Not only was the sales rep awesome, but the cells arrived right on time. They were packaged nicely into a box with dry ice and are exactly what we wanted.

Quote No.: AGK4005 Name: Coleen Thompson

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