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bEnd.3 | ||||
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| Product Name | bEnd.3 | |||
| Price | Get Quote | |||
| Product Code | bEND.3; b.End3; Bend.3; bEnd3; BEND3; brain-derived Endothelial cells.3 | |||
| Cat.No | ABC-TC0073 | Species | Mouse | |
| Size/Quantity | 1 vial | Biosafety Level | 1 | |
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description | bEnd.3 cells, also known as BEND3 cells, are endothelial cells originally obtained from mouse brain tissue afflicted with endothelioma.
Why choose bEnd.3 from AcceGen? bEnd.3 cells from AcceGen are maintained under optimal conditions by experienced operators, ensuring high viability and exceptional quality. They are provided in a sterile state, rigorously tested and confirmed negative for contaminants such as bacteria, yeast, mycoplasma, as well as pathogens like HIV and HBV, making them a reliable choice for research and experimentation. | |||
| Disease | Endothelioma | |||
| Source Organ | Brain | |||
| Recommended Medium And Supplement | DMEM + 10% FBS | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | FOR RESEARCH USE ONLY The bEnd.3 cell line holds versatile applications in both vascular and neuroscience research, playing a crucial role in understanding a wide range of human diseases linked to lymphatics, including endothelioma. These cells are particularly valuable for investigating blood-brain barrier (BBB) disruption and evaluating potential therapeutic interventions. Additionally, bEnd.3 cells are utilized in 3D cell culture models, offering researchers a valuable tool to study complex physiological interactions and disease mechanisms in a more representative in vitro environment. | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Cell Type | Endothelial | |||
| Growth Mode | Adherent | |||
| Product Type | Mouse Brain Cancer Cell Lines | |||
| Product Image |  | |||
These cells underwent transformation through infection with the NTKmT retrovirus vector, leading to the expression of polyomavirus middle T antigen. Their endothelial identity has been confirmed through the presence of von Willebrand factor expression and the uptake of fluorescently labeled low-density lipoprotein (LDL). These cells exhibit positivity for various endothelial-specific proteins such as PECAM-1, Endoglin, MECA-32, and Flk-1, as confirmed by FACS analysis. When exposed to inflammatory cytokines, bEnd.3 cells upregulate the expression of proteins such as ICAM-1, VCAM-1, and E-selectin. Remarkably, injection of these cells into mice induces the development of haemangiomas.- ONLINE INQUIRY
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