For research use only
| Cat No. | ABC-TC0071 |
| Product Type | Mouse Brain Cancer Cell Lines |
| Species | Mouse |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Disease | Neoplasms |
| Product Code | BC3 H1; BC3H-1; BC-3H-1; BC-3-H-I |
Recent data suggest that BC3H1 cells may more closely resemble cells in an arrested state of skeletal muscle differentiation than smooth muscle cells
BC3H1 is a murine tumor-derived cell line originating from an N-ethyl-N-nitrosourea-induced intracranial neoplasm in a C3H mouse. The cells exhibit an adherent, fibroblast-like morphology with two distinct shapes: flattened monolayers and spheroidal clusters. Although the tumor arose in smooth-muscle-like tissue, BC3H1 cells display both transcriptional and protein signatures of the skeletal muscle lineage and are arrested prior to terminal differentiation. Chromosomal analysis reveals a near-tetraploid karyotype (~74-82 chromosomes) with occasional fusion markers. Additionally, BC3H1 expresses muscle-contraction components, including acetylcholine receptors, creatine phosphokinase, adenylate phosphokinase, tropomyosin, and myosin heavy/light chains. These cells are cryopreserved at an early passage. The cells undergo stringent screening and testing procedures to ensure they are free from contamination by Mycoplasma, fungi, yeast, and bacteria.
| Product Code | BC3 H1; BC3H-1; BC-3H-1; BC-3-H-I |
| Species | Mouse |
| Cat.No | ABC-TC0071 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Brain |
| Disease | Neoplasms |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Brain Cancer Cell Lines |
BC3H1 myogenic cells serve as a robust in vitro model for studying muscle differentiation, intracellular signaling pathways, and contractile protein expression. They are widely employed in investigations of acetylcholine receptor regulation, myokinase (adenylate kinase) and creatine kinase activity, and cAMP-mediated differentiation mechanisms. Their unique arrest in differentiation makes them ideal for assays probing myogenic commitment, muscle signal transduction, and drug screening for neuromuscular modulation.
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