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Human Dopaminergic Neuron Cells

Product Name

Human Dopaminergic Neuron Cells

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Product Code

HDaNCs

Cat.No

ABC-TC5463

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Dopaminergic (DA) neurons are heterogenous groups of cells located from midbrain to forehead in mammalian central nerve system. They are the main source of dopamine, an important neurotransmitter responsible for mental and physiological regulations. The majority (~90%) of brain dopaminergic cells reside in the ventral part of mesencephalon. Dopaminergic neurons play an important role in regulating motor behavior, addiction, motivation, and reward system. Excessive dopamine in the brain is positively correlated with schizophrenia. While loss of dopaminergic neurons in substantia nigra in aged populations leads to Parkinson’s Disease (PD). Primary human fetal dopaminergic neurons have a better in vitro performance in survival and neuron reinnervation compared to iPS-derived dopaminergic neuron cells, making it ideal model for neurological study.
Why choose Human Dopaminergic Neuron Cells from AcceGen?
AcceGen human dopaminergic neuron cells are isolated from fetal brain tissue under authorization. Our dopaminergic neuron cells are selected in tyrosine free medium supplemented with a mixture of growth factors. Each vial contains ≥5×10^5 cells. Cells are assessed to express typical dopaminergic neuron marker tyrosine hydroxylase (TH), dopamine transporter (DAT) and mature neuron marker microtubule associated protein 2 (MAP2) by immunohistochemistry. Dopaminergic neuron cells are cryopreserved at passage 1 in cell culture media. The cells can be recovered in neuron maintenance media and guaranteed to further expand up to 4 passages following procedures provided by AcceGen. All cells are tested negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi.

RFP-Human Dopaminergic Neuron Cells are also provided in AcceGen.

Disease

Normal

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

For research use only
-Establish neurological disorders models, such as PD
-Drug screening
-Neuroprotection and neurotoxicity assay
-Co-culture with other neuron cells
-Study neural development and signaling

Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Growth Conditions

37 ℃, 5% CO2

Cell Type

Neuron

Growth Mode

Adherent

Product Type

Nervous Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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