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Primary Cells

Human Dopaminergic Neurons

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Human dopaminergic neuronal cells are isolated from fetal brain tissue obtained from agencies authorized to procure and distribute tissues for research. Dopaminergic neuronal cells are selected in tyrosine free medium supplemented with a mixture of growth factors. Actively growing population of cells are tested for tyrosine hydroxylase (TH) expression by immunocytochemistry. HDaNCs cells are provided […]
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Home | Primary Cells | Human Primary Cells | Nervous System Primary Cells | Human Dopaminergic Neurons
Product Code

HDaNCs
Species

Human
Cat.No

ABC-TC5463
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Neuron
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Nervous Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Description

Human Dopaminergic Neuron Cells
Human Dopaminergic Neuronal Precursor Cells (HDNPC) are derived from healthy human brain tissue. These cells are cryopreserved at passage one and delivered frozen. HDNPCs are associated with research related to various neurological diseases. In vitro, these cells should be avoided repeated freezing and thawing during the culture process.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • Human Dopaminergic Neuron Cells serve critical applications in: neurodegenerative disease studies (e.g., Parkinson’s disease mechanisms, therapeutic testing, and neuronal protection); drug discovery (screening drug effects on neuronal function/viability); cellular/molecular neuroscience research (exploring neuronal development and neurotransmitter release); Parkinson’s disease modeling (creating in vitro pathological models for target identification); toxicology studies (assessing compound neurotoxicity); cell therapy development (replacing damaged neurons); and elucidating neurological disorder mechanisms.

Frequently Asked Questions

  • What are human dopaminergic neurons, and what is their primary function?

    Human dopaminergic neurons are neurons that produce and release dopamine, a neurotransmitter crucial for motor control, reward, and motivation. They play a key role in the central nervous system.

  • How are human dopaminergic neurons typically obtained and cultured for research purposes?

    They are typically derived from stem cells, such as iPSCs or embryonic stem cells, through differentiation protocols. They are cultured in specialized media that support their growth and functionality

  • What are the main applications of Human Dopaminergic Neurons in scientific research?

    They are used to study neurodegenerative diseases like Parkinson’s, for drug screening, and to understand dopamine-related disorders. Additionally, they assist in developing and testing new therapies.

  • What are the key characteristics when culturing Human Dopaminergic Neurons?

    Key characteristics include the expression of markers like TH (tyrosine hydroxylase), DAT (dopamine transporter), and their ability to produce and release dopamine

  • What are the main challenges of culturing and experimenting with Human Dopaminergic Neurons?

    Challenges include maintaining cell viability and dopaminergic properties, preventing contamination, and replicating the complex in vivo environment of the brain in vitro.

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