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Immortalized Cell Lines

B-Lymphoblastoid Cell Lines (B-LCL)

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AcceGen's B-lymphoblastoid cell lines (B-LCL) are transformed by infection with Epstein-Barr virus (EBV) and can serve as a convenient source of antigen-presenting cells.
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Home | Immortalized Cell Lines | B-Lymphoblastoid Cell Lines (B-LCL)
Species

Human
Cat.No

ABI-TC048D
Product Category Immortalized Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphoblast
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Lymph
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Immortalized Cell Line
Immortalization Method

Epstein-Barr virus (EBV)

Description

B-Lymphoblastoid Cell Lines (B-LCL)B-Lymphoblastoid cell lines (B-LCL) are perpetually replicating B cell lines, originating from native B lymphocytes, that undergo transformation through Epstein-Barr virus (EBV) infection. These cell lines, established from peripheral blood samples, closely mimic activated B lymphocytes B-Lymphoblastoid Cell Lines (B-LCL)in terms of surface-expressed CD antigens. The transformative prowess of EBV lies in its ability to convert quiescent B-cells into self-sustaining, immortalized lymphoblastoid cells, retaining the virus in a latent state. This enables B-LCLs to persistently proliferate in vitro, providing valuable tools for research in immunology and virology.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • B-Lymphoblastoid cell lines (B-LCL) stand out as an exceptionally versatile resource with a wide range of research applications. Offering a bountiful supply of intact cells or derived DNA, B-LCLs unlock extensive possibilities for studies encompassing molecular genetics and functional analyses. Their utility extends to immunological research, providing a convenient reservoir of antigen-presenting cells suitable for tasks like mixed lymphocyte reactions and presenting peptide antigens. Moreover, B-LCLs hold significant promise in the relatively novel arena of rare disease research, effectively circumventing the limitations of scarce native cellular/genetic materials by offering a readily available and perpetually renewable alternative.

Frequently Asked Questions

  • What are B-Lymphoblastoid Cell Lines (B-LCL)?

    B-Lymphoblastoid Cell Lines (B-LCL) are immortalized cell lines derived from B lymphocytes, a type of white blood cell. These cell lines are created by infecting B cells with the Epstein-Barr virus (EBV), which induces the cells to proliferate indefinitely. B-LCLs are commonly used in research due to their stable growth properties and ability to produce monoclonal antibodies.

  • How are B-LCLs used in research?

    B-LCLs are widely used in various areas of biomedical research. They serve as a model system to study B cell biology, immune responses, and genetic disorders. Researchers use B-LCLs for producing monoclonal antibodies, investigating the effects of viral infections, and conducting genetic studies, including gene mapping and identifying disease-associated genetic variants. These cell lines are also valuable in pharmacogenomics for understanding drug responses and personalized medicine.

  • What are the advantages of using B-LCLs in research?

    Immortalization: B-LCLs can proliferate indefinitely, providing a consistent and renewable source of cells for long-term studies.

    Genetic Stability: They maintain a stable genetic background, making them suitable for genetic and genomic studies.

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