Home > Products > Immortalized Cell Lines >
B-Lymphoblastoid Cell Lines (B-LCL) | ||||
|---|---|---|---|---|
| Product Name | B-Lymphoblastoid Cell Lines (B-LCL) | |||
| Price | Get Quote | |||
| Cat.No | ABI-TC048D | Species | Human | |
| Size/Quantity | 1 vial | |||
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description | B-Lymphoblastoid cell lines (B-LCL) are perpetually replicating B cell lines, originating from native B lymphocytes, that undergo transformation through Epstein-Barr virus (EBV) infection. These cell lines, established from peripheral blood samples, closely mimic activated B lymphocytes
Why choose B-Lymphoblastoid Cell Lines (B-LCL) from AcceGen? AcceGen’s B-Lymphoblastoid Cell Lines (B-LCL) offer superior quality and viability. Prepared and incubated optimally by experts, our cells undergo rigorous mycoplasma screening and batch testing for sterility, count, viability, and authenticity using STR-PCR profiling, ensuring trustworthy and high-performance resources for your research. | |||
| Disease | Normal | |||
| Source Organ | Peripheral Lymph | |||
| Recommended Medium And Supplement | ABI-TM048D B-Lymphoblastoid Cell Lines (B-LCL) Medium Kit | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | FOR RESEARCH USE ONLY B-Lymphoblastoid cell lines (B-LCL) stand out as an exceptionally versatile resource with a wide range of research applications. Offering a bountiful supply of intact cells or derived DNA, B-LCLs unlock extensive possibilities for studies encompassing molecular genetics and functional analyses. Their utility extends to immunological research, providing a convenient reservoir of antigen-presenting cells suitable for tasks like mixed lymphocyte reactions and presenting peptide antigens. Moreover, B-LCLs hold significant promise in the relatively novel arena of rare disease research, effectively circumventing the limitations of scarce native cellular/genetic materials by offering a readily available and perpetually renewable alternative. | |||
| Immortalization Method | Epstein-Barr virus (EBV) | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Cell Type | Lymphoblast | |||
| Growth Mode | Suspension | |||
| Product Type | Immortalized Cell Line | |||
| Product Image |  | |||
in terms of surface-expressed CD antigens. The transformative prowess of EBV lies in its ability to convert quiescent B-cells into self-sustaining, immortalized lymphoblastoid cells, retaining the virus in a latent state. This enables B-LCLs to persistently proliferate in vitro, providing valuable tools for research in immunology and virology.Frequently Asked Questions
What are B-Lymphoblastoid Cell Lines (B-LCL)?
B-Lymphoblastoid Cell Lines (B-LCL) are immortalized cell lines derived from B lymphocytes, a type of white blood cell. These cell lines are created by infecting B cells with the Epstein-Barr virus (EBV), which induces the cells to proliferate indefinitely. B-LCLs are commonly used in research due to their stable growth properties and ability to produce monoclonal antibodies.
How are B-LCLs used in research?
B-LCLs are widely used in various areas of biomedical research. They serve as a model system to study B cell biology, immune responses, and genetic disorders. Researchers use B-LCLs for producing monoclonal antibodies, investigating the effects of viral infections, and conducting genetic studies, including gene mapping and identifying disease-associated genetic variants. These cell lines are also valuable in pharmacogenomics for understanding drug responses and personalized medicine.
What are the advantages of using B-LCLs in research?
Immortalization: B-LCLs can proliferate indefinitely, providing a consistent and renewable source of cells for long-term studies.
Genetic Stability: They maintain a stable genetic background, making them suitable for genetic and genomic studies.
- ONLINE INQUIRY
- PRODUCT REVIEWS
Fill out a request in the form below and we’ll get back to you within 24 hours with a quote.
