BEAS-2B Cell Line human
BEAS-2B Cell Line human
The BEAS-2B cell line is a well-known immortalized human cell line derived from the normal bronchial epithelium of a non-cancerous individual. It was established in 1988 by Curtis C. Harris’ research group through transfection with an adenovirus 12-SV40 hybrid virus, followed by continuous cell passaging for immortalization. Besides possessing typical epithelial characteristics, BEAS-2B cells also exhibit non-epithelial features, resembling mesenchymal stem cells. They express specific surface markers like CD73, CD90, CD44, and CD105, and demonstrate the ability to differentiate into both osteogenic and adipogenic lineages. Additionally, BEAS-2B cells effectively impede the proliferation of PHA-activated total T lymphocytes and Th1 lymphocytes derived from peripheral blood mononuclear cells (PBMCs).
Why choose BEAS-2B from AcceGen?
BEAS-2B from AcceGen is an ideal choice due to its high viability and quality. The cells are provided sterile and are handled by professional operators who ensure optimal incubation and cryopreservation conditions. Additionally, AcceGen implements rigorous quality control measures, guaranteeing reliable and consistent results for research and experimentation purposes.
|Recommended Medium And Supplement
ABI-TM4173 BEAS-2B Cell Line human Medium Kit
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FOR RESEARCH USE ONLY
The BEAS-2B cell line has found extensive applications as an in vitro cell model in respiratory disease research, particularly lung carcinogenesis. Being a bronchial epithelial cell line, it has been widely utilized to investigate the cellular and molecular mechanisms involved in lung carcinogenesis, including the study of epithelial-mesenchymal transition (EMT) and its role in cancer development. Furthermore, the BEAS-2B cell line has been employed as a valuable tool to study pneumococcal infections. Additionally, it serves as an in vitro model for assessing and screening various chemicals and biological agents with potential pulmonary toxicity or lung carcinogenicity. Notably, studies have utilized BEAS-2B cells to explore heavy metal-induced carcinogenesis, demonstrating that chronic exposure to metals such as arsenic (III) and chromium VI can induce malignant cell transformation and tumorigenesis.
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Immortalized Cell Lines
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