BEAS-2B Cell Line human

Description

BEAS-2B cell line is an immortalized human cell line derived from the normal bronchial epithelium and transformed with adenovirus 12-SV40 hybrid virus. They exhibit typical cobblestone epithelial morphology and retain characteristics of non-tumorigenic airway epithelium, including the expression of cytokeratins, E-cadherin, and tight junction proteins. BEAS-2B cells are widely used as an in vitro model to study airway biology, mucociliary function, oxidative stress, and responses to pollutants and pathogens. They respond robustly to inflammatory stimuli such as LPS, cigarette smoke extract, and allergens, making them valuable for respiratory toxicology, asthma, COPD, and lung cancer research. Although immortalized, BEAS-2B cells preserve many characteristics of normal bronchial epithelial cells, providing a balance between biological relevance and experimental convenience.