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Canine Bone Marrow Dendritic Cells

Product Name

Canine Bone Marrow Dendritic Cells

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1 vial

Biosafety Level


Shipping Info

Dry Ice


Liquid Nitrogen


Canine Bone Marrow Dendritic Cells, which originate from canine bone marrow haematopoietic cells under the influence of Flt3-ligand or GM-CSF, demonstrate distinctive characteristics. These cells express CD4 and CD8, as well as CD1c, CD11b, CD11c, and CD14. Interestingly, LPS stimulation positively impacts CD1c expression in these cells. Notably, when exposed to LPS (TLR4 ligand), these canine dendritic cells show an upregulation of MHC II and costimulatory molecules, indicating an immune response. On the ultrastructural level, transmission electron microscopy reveals fine needle-like dendrites at the cellular periphery and dense granules resembling periodic microstructures, serving as a defining feature for identifying canine dendritic cells.


Why choose Canine Bone Marrow Dendritic Cells from AcceGen?

Canine Bone Marrow Dendritic Cells possess high quality and viability, cryo-preserved at early passage with 5×106 cells in 1mL volume per vial. They are identified through immunofluorescence staining using CD11c antibodies and undergo rigorous quality control measures to ensure reliability and accuracy.



Source Organ

Bone Marrow

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Recommended Medium And Supplement
Citation Guide

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Canine Bone Marrow Dendritic Cells (caDC) hold significant promise in various applications due to dogs being a valuable experimental model for immune-mediated diseases, graft rejections, and cancers. Thoroughly characterizing caDC subsets and understanding their role in inflammation and immune responses is essential. Moreover, their potential as immunotherapy for canine cancers shows great potential, as they can be induced to stimulate tumor-specific CD8 T cells, opening avenues for innovative and targeted therapeutic approaches in veterinary oncology.

Growth Conditions

37 ℃, 5% CO2

Cell Type

DC Cell

Growth Mode


Product Type

Canine Primary Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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