Diseased Human Lung Fibroblasts, Idiopathic Pulmonary Fibrosis

Description

Diseased Human Lung Fibroblasts, Idiopathic Pulmonary Fibrosis are derived from the lung tissue of patients with idiopathic pulmonary fibrosis (IPF).These fibroblasts are human in origin, straight from the diseased lung tissue of IPF patients. These cells are long spindle-shaped or star-shaped, with typical fibroblast morphology, and the cells are connected to each other by extracellular matrix. They proliferate in an anchorage-dependent manner.Their karyotype is generally normal but can sometimes show instability due to disease progression. They show abnormal expression of fibrotic markers like alpha-smooth muscle actin (α-SMA) and fibronectin, detectable by immunostaining or PCR.In the pathological process of IPF, lung fibroblasts play a pivotal role by proliferating abnormally and secreting excessive amounts of extracellular matrix components, such as collagen and elastin, which ultimately lead to lung tissue fibrosis.