Diseased Human Lung Fibroblasts, Idiopathic Pulmonary Fibrosis

Description

Diseased Human Lung Fibroblasts, Idiopathic Pulmonary Fibrosis (lung fibroblasts) are derived from the lung tissue of patients with idiopathic pulmonary fibrosis (IPF). These fibroblasts are human in originThe cells are human in origin, straight from. These cells are long spindle-shaped or star-shaped, with typical fibroblast morphology, and embedded within and interacting with the extracellular matrix. They proliferate in an anchorage-dependent manner. Their karyotype is generally normal but can sometimes show instability due to disease progression. They show abnormal expression of fibrotic markers like alpha-smooth muscle actin (α-SMA) and fibronectin, detectable by immunostaining or PCR. In the pathological process of IPF, lung fibroblasts play a pivotal role by proliferating abnormally and secreting excessive amounts of extracellular matrix components, such as collagen type I/III and fibronectin, which ultimately lead to lung tissue fibrosis. These human lung fibroblasts serve as a disease-relevant in vitro model for studying fibrotic mechanisms, fibroblast–lung microenvironment interactions, and for evaluating anti-fibrotic therapeutic strategies.