HighQC™ Human Endothelial Progenitor Cell

Description

HighQC™ Human Endothelial Progenitor Cell (EPCs) are primary cells isolated from the peripheral blood or bone marrow of healthy adult donors, they represent a rare population of circulating cells capable of differentiating into mature endothelial cells. EPCs exhibit a spindle-shaped morphology during early culture, transitioning to a cobblestone-like appearance upon maturation. EPCs co-express progenitor-associated markers such as CD34 and CD133 with endothelial lineage markers including VEGFR-2 (KDR) and CD144 (VE-cadherin). Upon maturation, they upregulate markers of fully differentiated endothelial cells, such as CD31 (PECAM-1) and von Willebrand factor (vWF). Functionally, EPCs contribute to postnatal vasculogenesis and vascular repair, homing to ischemic tissues and supporting neovascularization through incorporation into vessel walls and secretion of pro-angiogenic factors. Due to their regenerative potential, EPCs are widely studied for therapeutic angiogenesis in myocardial infarction, peripheral artery disease, ischemic stroke, and diabetic foot ulcers, and serve as a robust model for vascular biology and tissue engineering applications.