HighQC™ Human IPSC From Foreskin Fibroblasts/ Male/ Retrovirus)

Description

HighQC™ Human iPSC (From Fibroblast/ Male/ Retrovirus) is an induced pluripotent stem cell line derived from dermal fibroblasts of a healthy male donor, using morphological selection criteria without the use of fluorescent markers or drug selection. These cells are generated by transducing four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc, into human fibroblasts using retroviral vectors. They exhibit expression of the pluripotency markers SSEA-3 and Nanog. Additionally, the cell line demonstrates strong endogenous alkaline phosphatase activity. While it retains the potential to differentiate into lineages of all three germ layers, the cell line remains a valuable resource for investigating cellular reprogramming and early lineage commitment. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria.