Human Colorectal Tumor Carcinoma Associated Fibroblasts (CAFs) are primary cells isolated from human colon tumor tissues. These cells exhibit spindle-shaped morphology and adherent culture properties. Functionally, they actively remodel the extracellular matrix (ECM) and secrete factors like HGF and IL-6, influencing tumor growth, angiogenesis, and chemoresistance. Markers like α-SMA, FAP, and vimentin are commonly used for characterization. This CAF model provides a physiologically relevant tool for studying tumor-stroma interactions.
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