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Primary Cells

Human Intestinal Myofibroblasts

  • For research use only

Cat No.

ABC-TC3880
Product Type

Intestinal Cells
Cell Type

MyoFibroblast
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Intestine
Disease

Normal
Storage

Liquid Nitrogen

Human Intestinal Myofibroblasts enable studies of gut fibrosis, wound healing, and epithelial–mesenchymal interactions in gastrointestinal research models.

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  • Human Intestinal Myofibroblasts
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Home | Primary Cells | Human Primary Cells | Digestive System Primary Cells | Human Intestinal Myofibroblasts

Description

Human Intestinal Myofibroblasts (HIMFs) are isolated from whole adult human intestines. They play a critical role in intestinal growth and development, repair, tumorigenesis, water and electrolyte transport, inflammation, and fibrosis. HIMFs can secrete the epidermal growth factor receptor ligand Amphiregulin (AREG) under the induction of TNF-α. In addition, in intestinal inflammation (such as Crohn’s disease), myofibroblasts are activated, accompanied by excessive deposition of extracellular matrix (ECM) components (including collagen and fibronectin), ultimately driving the process of intestinal fibrosis. TGF-β/Smad signaling plays a central role in this fibrotic response, which also involves cross-talk between immune cells (notably macrophages) and epithelial cells. In the human intestine, myofibroblasts can be identified by specific myofibroblast markers and are widely used as a cellular model to study stromal–epithelial interactions and tissue remodeling.

Product Code

H-InMyoFib
Species

Human
Cat.No

ABC-TC3880
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

MyoFibroblast
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Intestine
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Intestinal Cells
Key Features

Backed by AcceGen advanced technology
Ship cryopreserved cells in dry ice
Quality-tested for accurate results
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Intestinal Myofibroblasts can be used to establish intestinal disease models, such as inflammatory bowel disease (IBD), intestinal fibrosis and colorectal cancer, which helps to further explore disease mechanisms and potential therapeutic targets. In addition, these cells can also be used as active ingredients for constructing in vitro intestinal models or biological scaffolds to simulate the intestinal microenvironment to study drug absorption, toxicity testing or host-microorganism interactions.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What are myofibroblasts?

    Myofibroblasts are specialized mesenchymal cells that exhibit features of both fibroblasts and smooth muscle cells. They play key roles in extracellular matrix production, tissue remodeling, and wound healing, particularly in intestinal stromal environments.

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