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Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Relapsed/Refactory)

  • BSL

    1

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Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells are density separated by Ficoll-Paque from Mantle Cell Lymphoma peripheral blood. Mantle Cell Lymphoma PBMCs are available in untreated and relapsed/refractory stages.
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Relapsed/Refactory)
Species

Human
Cat.No

ABC-TC3890
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Mantle Cell Lymphoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Relapsed/Refractory) are derived from peripheral blood samples of patients with relapsed/refractory mantle cell lymphoma (MCL). Morphological analysis shows that this cell population mainly consists of atypical small lymphocytes, and its immunophenotype displays typical MCL features: Cyclin D1 and CD5 are diffusely and positively expressed, while SOX-11 is positive in some cases. The combination of these three markers provides a crucial basis for diagnosis.Its core genetic feature is the t(11;14)(q13;q32) chromosomal translocation, which leads to abnormal overexpression of the cyclin D1 (CCND1) gene, thereby driving the cell cycle out of control.Additionally, these cells exhibit persistent abnormal activation of the B cell receptor (BCR) signaling pathway, significantly enhancing tumor B cell survival by continuously activating downstream pathways such as PI3K/AKT and MAPK.

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Citation

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Application

  • Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Relapsed/Refactory) can be used for high-throughput screening and efficacy verification of targeted drugs (such as BTK inhibitors, PI3K inhibitors), as well as sensitivity assessment of new immunotherapies (CAR-T, dual antibodies). In addition, these cells can also be used for drug resistance mechanism research and biomarker discovery to predict treatment response or relapse, including TP53 mutations and epigenetic changes.

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