Human Sickle Cell Anemia Peripheral Blood Mononuclear Cells

Description

Human Sickle Cell Anemia Peripheral Blood Mononuclear Cells (PBMCs) are derived from the peripheral blood of patients with sickle cell anemia (SCA).Peripheral blood from sickle cell anemia patients. Typical mononuclear cells, small and round, suspension growth.They are isolated by density gradient centrifugation and mainly contain lymphocytes (T cells, B cells, NK cells) and monocytes.Altered cytokine profiles with increased proinflammatory cytokines like TNF-α, IL-1β, IL-6; possible oxidative stress markers elevated Under the continuous influence of pathological factors such as chronic hemolysis, PBMCs in SCA patients show obvious functional abnormalities such as dysregulated cytokine secretion, which may in turn affect multiple physiological processes such as immune regulation.Chronic hemolysis and inflammatory environment drive functional dysregulation of PBMCs, contributing to immune dysregulation in SCA.