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Primary Cells

Human Valvular Interstitial Cells

  • For research use only

Cat No.

ABC-TC3866
Product Type

Cardiac Cells
Cell Type

Interstitial Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Disease

Normal
Storage

Liquid Nitrogen

Human Valvular Interstitial Cells from heart valves express smooth muscle actin and support valve biology, fibrosis, and calcification studies.

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  • Human Valvular Interstitial Cells
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Description

Human Valvular Interstitial Cells (hVICs) are primary fibroblast-like cells isolated from normal human aortic valve tissue. These cells exhibit fibroblast-like morphology with elongated, spindle-shaped profiles under standard culture conditions. Functionally, hVICs participate in valvular homeostasis, but under pathological stimuli, they contribute to calcific aortic valve disease (CAVD) through osteogenic differentiation, a process marked by upregulated alkaline phosphatase (ALP) and collagen type I expression. Inflammatory pathways such as NLRP3 inflammasome activation and TGF-β signaling, further exacerbate extracellular matrix (ECM) stiffening and calcium deposition, both hallmarks of CAVD progression. Immunophenotyping confirms their identity through positive staining for vimentin and α-SMA, while remaining negative for endothelial markers such as Factor VIII. hVICs require careful handling, repeated freeze-thaw cycles should be avoided to maintain optimal viability.

Species

Human
Cat.No

ABC-TC3866
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Interstitial Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Cardiac Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Valvular Interstitial Cells (hVICs) are extensively used as an in vitro model to investigate the pathogenesis of calcific aortic valve disease (CAVD). Their responsiveness to pathological cues, including hyperlipidemia, inflammation, and mechanical stress, makes them ideal for studying osteogenic transdifferentiation, extracellular matrix (ECM) remodeling, and mechanotransduction. These cells are widely utilized in preclinical screening of potential therapeutic candidates aimed at halting or reversing valve calcification. Their ability to recapitulate disease-associated phenotypes, such as calcific nodule formation and α-SMA expression, makes them valuable for studying early-stage valve degeneration and potential intervention points.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What is the source of Human Valvular Interstitial Cells?

    These cells are derived from the heart valve tissue of healthy human donors or patients undergoing surgery.

  • Are Human Valvular Interstitial Cells suitable for valve disease modeling and research?

    Yes, these cells are commonly used for studying valve-related diseases, fibrosis, and calcification.

  • What culture conditions are recommended for Human Valvular Interstitial Cells?

    These cells should be cultured in a fibroblast-specific medium with growth supplements to maintain viability.

  • Can Human Valvular Interstitial Cells be used for drug testing related to heart valve therapies?

    Yes, they are suitable for preclinical drug testing aimed at treating or preventing valvular diseases.

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