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The IGR-1 cell line is derived from a metastatic melanoma tumor in a 42-year-old male’s groin lymph node. These cells exhibit tumorigenic characteristics in nude mice and harbor a heterozygous BRAFV600K mutation, while remaining wild type with respect to BRAFV600E. In culture, IGR-1 cells present as adherent, epithelial-like cells, growing in monolayers with dendritic branching until they reach confluence. Upon contact inhibition, they assume a smooth and round morphology. Subculturing of these cells is typically performed at a ratio of 1:3 to 1:5 every 3-5 days using trypsin/EDTA.


Why choose IGR-1 from AcceGen?

The IGR-1 cell line from AcceGen is characterized by its high viability and quality, meticulously nurtured under optimal conditions. Continuous daily monitoring ensures the absence of bacterial and fungal contamination, while a PCR-based assay guarantees mycoplasma-free status. Furthermore, the cell line’s identity is verified through STR analysis, ensuring its authenticity and reliability for research applications.



Source Organ

Groin Lymph Node

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Liao, Y., Jia, X., Ren, Y., Deji, Z., Gesang, Y., Ning, N., Feng, H., Yu, H. and Wei, A., 2021. Suppressive role of microRNA-130b-3p in ferroptosis in melanoma cells correlates with DKK1 inhibition and Nrf2-HO-1 pathway activation. Human Cell, pp.1-13.

Gill, Jennifer G et al. “A Short Isoform of Spermatogenic Enzyme GAPDHS Functions as a Metabolic Switch and Limits Metastasis in Melanoma.” Cancer research vol. 82,7 (2022): 1251-1266. doi:10.1158/0008-5472.CAN-21-2062



The IGR-1 cell line plays a pivotal role in advancing our knowledge of human melanoma cell biology. It is instrumental in probing the intricate metabolism of human melanoma cells and dissecting the critical factors and mechanisms that drive their proliferation. Through these applications, IGR-1 contributes to crucial insights into melanoma research, paving the way for potential therapeutic interventions and enhanced understanding of this challenging disease.

Growth Conditions

37 ℃, 5% CO2

Growth Mode


Product Type

Human Melanoma Cell Lines

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