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Cell Separation
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The successful development of CAR-T cell therapy necessitates a significant quantity of highly-purified and viable T cells. CAR-T immunotherapy involves the genetic engineering of T cells with chimeric antigen receptors (CARs) to specifically target and eradicate cancer cells. To facilitate pre-clinical testing on various scales and enable clinical applications, it is crucial to obtain a substantial number of T cells with high purity, recovery, and viability.
The isolation of immune cells employs diverse techniques to separate specific cell populations for both research and therapeutic purposes. Immunomagnetic cell separation is a widely used method that utilizes magnetic particles conjugated with antibodies or ligands to selectively label and separate target immune cells from a heterogeneous cell population (as shown in Figure 1). This technique enables the isolation of highly purified immune cell subsets, facilitating their characterization, functional studies, and potential applications in immunotherapy.
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Figure 1. Comparison of Positive Selection and Negative Selection
AcceGen specializes in providing advanced cell enrichment technologies that serve as a robust foundation for your workflow. Our offerings enabling the efficient enrichment of diverse immune cell subsets such as T cells, natural killer (NK) cells, and regulatory T cells (Treg).
By leveraging AcceGen’s comprehensive solutions for Cell and Gene Therapy Manufacturing, you can propel your research forward with confidence, driving it closer to clinical applications. Our state-of-the-art tools and expertise empower you to bring your innovative discoveries to the forefront of Cell and Gene Therapy Manufacturing.
Application
- Provides cell isolation solutions for small to large-scale cell therapy manufacturing, ensuring efficient and reliable isolation of T cells for research and clinical applications.
- Supports in vitro drug testing and hybridoma production for antibody research.