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| Product Code | 4T1-A; 4T1.0; 4T1/WT |
| Species | Mouse |
| Cat.No | ABC-TC0014 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Breast |
| Disease | Breast Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Breast Cancer Cell Lines |
The 4T1 cell line is a highly aggressive breast cancer model derived from the mammary gland tissue of a BALB/c mouse. These cells are highly tumorigenic and invasive, with the ability to spontaneously metastasize to lymph nodes, blood, liver, lung, brain, and bone, mimicking human breast cancer growth and metastasis. The cells exhibit molecular characteristics resembling triple-negative breast cancer, lacking estrogen receptor (ER), progesterone receptor (PgR), and epidermal growth factor receptor 2 (ErbB2). They express keratin, vimentin, and N-cadherin, showing an epithelial/mesenchymal phenotype. 4T1 cells grow as adherent monolayers in DMEM or RPMI-1640 medium with fetal bovine serum. These cells are non-viral, with no reports of HPV, HIV, or EBV infections.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
The 4T1 cell line, derived from a murine mammary carcinoma, is widely used to establish syngeneic tumor models in immunocompetent BALB/c mice, mimicking stage IV human triple-negative breast cancer (TNBC). 4T1 cells can be orthotopically transplanted into the mammary fat pad to form primary tumors, followed by spontaneous metastasis to distant organs (e.g., lungs, liver), making it suitable for both non-surgical studies of primary tumor progression and post-surgical models of metastatic recurrence.
