For research use only
| Cat No. | ABC-TC0014 |
| Product Type | Mouse Breast Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Mouse |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Breast |
| Disease | Breast Cancer |
| Product Code | 4T1-A; 4T1.0; 4T1/WT |
4T1 murine mammary carcinoma cells metastasize to lung, liver, lymph nodes, and brain, supporting immuno-oncology and metastasis research models.
4T1 is a highly tumorigenic and invasive mouse mammary carcinoma cell line derived from a spontaneously arising mammary tumor in BALB/c mice. These adherent cells exhibit epithelial morphology and form tight monolayers in culture. The 4T1 line is highly tumorigenic and shows aggressive metastatic potential, particularly to lung, liver, bone, and brain, mimicking human breast cancer growth and metastasis, making it a widely used model of stage IV breast cancer. The cells exhibit molecular characteristics resembling triple-negative breast cancer, lacking estrogen receptor (ER), progesterone receptor (PgR), and epidermal growth factor receptor 2 (ErbB2). They express markers typical of basal-like breast cancer, including cytokeratins and vimentin. Due to its immunocompetent origin, 4T1 cells are valuable in studying tumor-immune interactions and metastatic mechanisms.
| Product Code | 4T1-A; 4T1.0; 4T1/WT |
| Species | Mouse |
| Cat.No | ABC-TC0014 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Breast |
| Disease | Breast Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Breast Cancer Cell Lines |
4T1 cells are extensively used as a syngeneic mouse model for breast cancer metastasis and immunotherapy research. Serving as an animal model for locally advanced breast cancer (stage III), their ability to spontaneously metastasize after orthotopic implantation enables studies on tumor progression, immune evasion, and response to chemotherapeutics and immune checkpoint inhibitors. The ease of transplanting cells into the mammary gland allows for the growth of primary tumors in the anatomically correct site. Furthermore, the model supports investigations into cancer stem cells, tumor microenvironment, and anti-metastatic drug development, making it a versatile tool for preclinical breast cancer research.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
