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Tumor Cell Lines

4T1

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T1 is a 2-Amino-6-purinethiol resistant cell line selected from the 410.4 Tumor without mutagen treatment. When injected into BALB/c mice, 4T1 spontaneously produces highly metastatic tumors that can metastasize to the lung, liver, lymph nodes and brain while t.
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Product Code

4T1-A; 4T1.0; 4T1/WT

Species

Mouse

Cat.No

ABC-TC0014

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Cell Type

Epithelial

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Breast

Disease

Breast Cancer

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Mouse Breast Cancer Cell Lines

Description

4T1The 4T1 cell line is a highly aggressive breast cancer model derived from the mammary gland tissue of a BALB/c mouse. These cells are highly tumorigenic and invasive, with the ability to spontaneously metastasize to lymph nodes, blood, liver, lung, brain, and bone, mimicking human breast cancer growth and metastasis. The cells exhibit molecular characteristics resembling triple-negative breast cancer, lacking estrogen receptor (ER), progesterone receptor (PgR), and epidermal growth factor receptor 2 (ErbB2). They express keratin, vimentin, and N-cadherin, showing an epithelial/mesenchymal phenotype. 4T1 cells grow as adherent monolayers in DMEM or RPMI-1640 medium with fetal bovine serum. These cells are non-viral, with no reports of HPV, HIV, or EBV infections.

Citation

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Application

  • The 4T1 cell line, derived from a murine mammary carcinoma, is widely used to establish syngeneic tumor models in immunocompetent BALB/c mice, mimicking stage IV human triple-negative breast cancer (TNBC). 4T1 cells can be orthotopically transplanted into the mammary fat pad to form primary tumors, followed by spontaneous metastasis to distant organs (e.g., lungs, liver), making it suitable for both non-surgical studies of primary tumor progression and post-surgical models of metastatic recurrence.

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