For research use only
| Cat No. | ABC-H0026Y |
| Product Type | Mouse Breast Cancer Cell Lines |
| Cell Type | Fibroblast |
| Species | Mouse |
| Growth Conditions | 37 ℃, 5% CO2 |
| Product Code | L-WRN, LWRN Cells, L-WRN Conditioned Medium Producer Cells, Wnt3a R-spondin3 Noggin Expressing Cells, Intestinal Organoid Support Cells |
Utilize L-WRN cells to support long-term organoid culture, Wnt pathway activation, and stem cell niche modeling in gastrointestinal systems research.
L-WRN is a genetically modified mouse fibroblast cell line derived from L cells originally isolated from the subcutaneous connective tissue of a C3H/An mouse. These adherent cells display a spindle-shaped, fibroblast-like morphology and support continuous passaging. Engineered to stably express Wnt3a, R-spondin 3, and Noggin—key factors that maintain stemness and promote intestinal organoid growth—L-WRN cells serve primarily as a source of conditioned medium enriched with stem cell niche signals. While they retain fibroblast markers like vimentin, they lack significant expression of epithelial or neural markers. Widely used in stem cell and organoid research, L-WRN cells are essential for generating and sustaining 3D cultures of intestinal and other epithelial tissues.
| Product Code | L-WRN, LWRN Cells, L-WRN Conditioned Medium Producer Cells, Wnt3a R-spondin3 Noggin Expressing Cells, Intestinal Organoid Support Cells |
| Species | Mouse |
| Cat.No | ABC-H0026Y |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Fibroblast |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Mouse Breast Cancer Cell Lines |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
The L-WRN cell line is widely applied in regenerative medicine, developmental biology, and disease modeling. Researchers use L-WRN cells to maintain pluripotent stem cells, induce organoid formation, and study Wnt signaling, which is essential in tissue regeneration and embryogenesis. It is also pivotal in protocols for producing lineage-specific cells for research and therapeutic applications.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
