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L-WRN | ||||
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| Product Name | L-WRN | |||
| Price | Get Quote | |||
| Cat.No | ABC-H0026Y | Species | Mouse | |
| Size/Quantity | 1 vial | Biosafety Level | 1 | |
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description | L-WRN is a fibroblast-like cell that was isolated from the areolar of a male mouse. The L-WRN cell line is a type of murine stromal cell line commonly used in stem cell research and tissue engineering. L-WRN cells are genetically modified to express three key signaling proteins: Wnt3a, R-Spondin1, and Noggin. These proteins play crucial roles in the regulation of stem cell self-renewal and differentiation. By providing a supportive microenvironment rich in these signaling factors, L-WRN cells can maintain and expand various types of stem cells, including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), in an undifferentiated state.
Additionally, L-WRN cells are often used as feeder layers in culture systems to promote the growth and maintenance of pluripotent stem cells. Their ability to sustain stem cell pluripotency makes L-WRN cells valuable tools for studying stem cell biology, developmental processes, and regenerative medicine applications.
Why choose L-WRN from AcceGen?
Mycoplasma-Free Assurance Rest easy knowing that all L-WRN cells undergo rigorous testing, and the results unequivocally confirm the absence of mycoplasma contamination. Your research demands a pristine environment, and we deliver on that commitment.
Bacterial, Yeast, and Fungal Negativity L-WRN cells go through meticulous scrutiny, testing negative not only for mycoplasma but also for bacteria, yeast, and fungi. This stringent quality control ensures a contamination-free culture, providing a reliable foundation for your biomedical investigations. | |||
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. | |||
| Recommended Medium And Supplement | DMEM + 10% FBS | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | FOR RESEARCH USE ONLY
AcceGen’s L-WRN cell lines have diverse applications in scientific research, particularly in the fields of stem cell biology, regenerative medicine, and developmental biology. Here are some key applications of L-WRN cells in science research:
Stem Cell Maintenance L-WRN cell lines are often used as feeder cells to support the maintenance and expansion of pluripotent stem cells, such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). The L-WRN cell lines secretes factors that promote the self-renewal of stem cells.
Embryoid Body Formation Researchers utilize L-WRN cells to induce the formation of embryoid bodies, three-dimensional aggregates of differentiating stem cells. This mimics early stages of embryonic development and aids in studying lineage commitment and differentiation.
Directed Differentiation of Stem Cells L-WRN cells contribute to the directed differentiation of pluripotent stem cells into specific cell lineages, such as neural, cardiac, or mesodermal lineages. This is essential for generating differentiated cell types for various applications.
Regenerative Medicine In the field of regenerative medicine, L-WRN cells play a role in generating specific cell types for potential therapeutic applications. They contribute to the development of protocols for producing cells that can be used for tissue repair or replacement.
Study of Wnt Signaling Pathway L-WRNcells are engineered to overexpress Wnt3a, R-spondin, and Noggin, creating an environment rich in Wnt signaling pathway components. This allows researchers to study the effects of Wnt signaling on cellular processes, including stem cell behavior and tissue regeneration.
Developmental Biology Research The L-WRN cell line is valuable for studying various aspects of developmental biology, including organogenesis, tissue patterning, and morphogenesis. It provides a controlled environment for investigating the molecular and cellular events underlying embryonic development.
In Vitro Disease Modeling L-WRN cells contribute to in vitro disease modeling, allowing researchers to mimic aspects of tissue development and study disease mechanisms. This is particularly relevant for understanding genetic disorders and developmental abnormalities.
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| Growth Conditions | 37 ℃, 5% CO2 | |||
| Cell Type | Fibroblast | |||
| Growth Mode | Adherent | |||
| Product Type | Mouse Breast Cancer Cell Lines | |||
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