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BEAS-2B Cell Line human

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BEAS-2B cells were derived from normal bronchial epithelium obtained from autopsy of non-cancerous individuals. Cells were infected with a replication-defective SV40/adenovirus 12 hybrid and cloned. Squamous differentiation can be observed in response to serum. This ability can be used for screening chemical and biological agents inducing or affecting differentiation and/or carcinogenesis. The cell line has […]
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Home | Immortalized Cell Lines | BEAS-2B Cell Line human
Species

Human
Cat.No

ABI-TC4173
Product Category Immortalized Cell Lines
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Bronchia
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Immortalized Cell Lines

Description

BEAS-2B cell line is an immortalized human cell line derived from the normal bronchial epithelium of a 35-year-old Caucasian male. They exhibit typical epithelial characteristics but also show mesenchymal stem cell-like features, expressing surface markers such as CD73, CD90, CD44, and CD105. Morphologically, BEAS-2B cells appear polygonal in culture. They are cultured under standard conditions of 37°C with 5% CO2. The cell line is non-tumorigenic and does not form tumors when transplanted into immunodeficient mice. BEAS-2B cells maintain a diploid karyotype with stable chromosomal structure and exhibit no mutations associated with malignancy. BEAS-2B cells have been shown to inhibit the proliferation of PHA-activated T lymphocytes and Th1 lymphocytes from PBMCs.

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Application

  • The BEAS-2B cell line is widely used in respiratory disease research, particularly lung carcinogenesis. Being a bronchial epithelial cell line, it has been widely utilized to study the mechanisms of lung carcinogenesis, including the study of epithelial-mesenchymal transition (EMT) and its role in cancer development. Furthermore, the BEAS-2B cell line has been employed as a valuable tool to study pneumococcal infections. Additionally, it serves as an in vitro model for screening chemicals and biological agents for toxicity or carcinogenicity carcinogenicity. Notably, studies have utilized BEAS-2B cells to explore heavy metal-induced carcinogenesis, demonstrating that chronic exposure to metals such as arsenic (III) and chromium VI can induce malignant cell transformation and tumorigenesis.

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