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COV362

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A human ovarian epithelial-endometroid carcinoma cell line established from a pleural effusion. Anchorage-independent growth in agar has been reported. The cell line COV362.4 is a subclone of this cell line.
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Home | Tumor Cell Lines | Human Tumor Cell Lines | COV362
Product Code

Cov362; COV-362
Species

Human
Cat.No

ABC-TC5589
Product Category Tumor Cell Lines
Size/Quantity

1 vial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Ovary
Disease

Ovarian Epithelial Endometroid Cancer
Storage

Liquid Nitrogen
Product Type

Human Ovarian Cancer Cell Lines

Description

Cov362
COV362 is a human ovarian epithelial-endometrioid carcinoma cell line that was originally isolated from the pleural effusion of an age-unspecified female patient with high-grade ovarian serous adenocarcinoma (HGSOC). COV362 exhibits epithelial-like morphology with polygonal and fusiform cell shape and adherent culture properties. It demonstrates anchorage-independent growth in agar and exhibits prominent structural rearrangements in chromosomes 1, 3, 7, and 11. COV362 carrying TP53 and BRCA1 gene mutation. It is tumorigenic in a nude mouse model but is normally considered as either subcutaneous or intraperitoneal xenografts.
AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • The COV362 cell line finds diverse applications, serving as a valuable tool in the creation of xenograft models for preclinical drug development insights, exploring the impact of estrogen supplementation on ovarian cancer behavior and targeted therapeutic responses. Additionally, it proves crucial in genomic analyses, reflecting the prevalent high-grade serous ovarian cancer (HGSOC) subtype. Moreover, COV362 serves as a robust model for testing potential therapies, including innovative approaches like CAR-T cell therapies.

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