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COV434

Product Name

COV434

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Product Code

COV-434; COV 434

Cat.No

ABC-TC0191

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

COV434 is a human ovarian cancer cell line that was initially believed to originate from a granulosa cell tumor. However, a recent 2021 report suggested that it is more likely derived from small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). These cells exhibit a stable hyperdiploid karyotype characterized by a gain of chromosome 5, with a subclone showing an additional gain of chromosome 22q. Notably, COV434 cells lack both SMARCA4 and SMARCA2 proteins, which are the ATPase subunits of the SWI/SNF complex. The reintroduction of SMARCA4 into COV434 cells significantly suppressed their growth. When transplanted into mice, COV434 cells induce rapid tumor growth accompanied by increased serum calcium levels, indicative of SCCOHT-associated hypercalcemia.

 

Why choose COV434 from AcceGen?

COV434 cells from AcceGen are an excellent choice due to their high quality and viability. They are prepared under optimal conditions by professional operators, ensuring sterility and maintaining their integrity. Advanced cryopreservation techniques are employed for safe transportation and storage. Additionally, AcceGen conducts rigorous quality control measures to ensure the reliable and consistent performance of COV434 cells.

Disease

Ovarian Small Cell Cancer

Source Organ

Ovary

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

FOR RESEARCH USE ONLY

The COV434 cell line has several valuable applications in ovarian research. Firstly, it can serve as an in vitro model to evaluate the impact of potential therapeutic strategies on the growth and survival of ovarian cancer cells. Researchers can use COV434 cells to test the efficacy of various treatments in inhibiting proliferation. Additionally, studying COV434 cells enables the investigation of signaling pathways associated with ovarian cancer cell proliferation, potentially uncovering new therapeutic targets. Furthermore, COV434 cells express Toll-like receptors (TLRs) and constitutively secrete IL-8, making them suitable for immune research. Their ability to mount an inflammatory response at the transcriptional level upon exposure to pathogen-associated molecular patterns (PAMPs) highlights their potential as the valuable material for studying immune responses.

Growth Conditions

37 ℃, 5% CO2

Growth Mode

Adherent

Product Type

Human Ovarian Cancer Cell Lines

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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