COV-434; COV 434
COV434 is a human ovarian cancer cell line that was initially believed to originate from a granulosa cell tumor. However, a recent 2021 report suggested that it is more likely derived from small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). These cells exhibit a stable hyperdiploid karyotype characterized by a gain of chromosome 5, with a subclone showing an additional gain of chromosome 22q. Notably, COV434 cells lack both SMARCA4 and SMARCA2 proteins, which are the ATPase subunits of the SWI/SNF complex. The reintroduction of SMARCA4 into COV434 cells significantly suppressed their growth. When transplanted into mice, COV434 cells induce rapid tumor growth accompanied by increased serum calcium levels, indicative of SCCOHT-associated hypercalcemia.
Why choose COV434 from AcceGen?
COV434 cells from AcceGen are an excellent choice due to their high quality and viability. They are prepared under optimal conditions by professional operators, ensuring sterility and maintaining their integrity. Advanced cryopreservation techniques are employed for safe transportation and storage. Additionally, AcceGen conducts rigorous quality control measures to ensure the reliable and consistent performance of COV434 cells.
Ovarian Small Cell Cancer
|Recommended Medium And Supplement
DMEM + 2mM Glutamine + 10% FBS
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FOR RESEARCH USE ONLY
The COV434 cell line has several valuable applications in ovarian research. Firstly, it can serve as an in vitro model to evaluate the impact of potential therapeutic strategies on the growth and survival of ovarian cancer cells. Researchers can use COV434 cells to test the efficacy of various treatments in inhibiting proliferation. Additionally, studying COV434 cells enables the investigation of signaling pathways associated with ovarian cancer cell proliferation, potentially uncovering new therapeutic targets. Furthermore, COV434 cells express Toll-like receptors (TLRs) and constitutively secrete IL-8, making them suitable for immune research. Their ability to mount an inflammatory response at the transcriptional level upon exposure to pathogen-associated molecular patterns (PAMPs) highlights their potential as the valuable material for studying immune responses.
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Human Ovarian Cancer Cell Lines
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