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| Product Code | B4G12 |
| Species | Human |
| Cat.No | ABC-TC0334 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Corneal Cell Lines |
HCEC-B4G12 is an SV40-transformed human corneal endothelial cell line derived from the parental HCEC-12, which was originally established in 2005 from the posterior corneal of a 91-year-old Caucasian female donor. HCEC-B4G12 exhibits epithelial-like morphology with polygonal cell shape and adherent growth characteristics. Genomic analysis confirms stable integration of the SV40 large T antigen, which likely confers immortalization through p53/Rb pathway disruption. Despite this transformation, HCEC-B4G12 retains corneal endothelial differentiation markers. The cells express high levels of collagen type IV and minimal levels of collagen type III, making them a valuable model for studying corneal endothelial characteristics.
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HCEC-B4G12 cells, serving as a robust in vitro model for differentiated human corneal endothelial cells (HCECs), and are widely used in studies aimed at presering corneal function under stress conditions. They play a pivotal role in investigating the effects of oxidative stress, inflammation, and cellular aging on corneal endothelial health and viability. Given that inflammation being a major contributor to corneal endothelial dysfunction and blindness, HCEC-B4G12 provides a powerful tool to explore the cellular mechanisms underlying endothelial damage. These provides essential insights for the development of targeted therapeutic strategies to prevent or mitigate corneal degeneration, improve ocular surface health, and combat vision-threatening conditions.
