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HighQC™ Human Mesenchymal Stem Cell-Expressing OCT3/4

Product Name

HighQC™ Human Mesenchymal Stem Cell-Expressing OCT3/4

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Cat.No

ABC-SC0032T

Species

Human

Size/Quantity

1 vial

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

It is well-established that induced pluripotent stem cells may be generated by co-transfection of four genes: Oct3/4, Sox2, Kfl4 and c-Myc, into somatic adult cells resulting in re-programming of these cells to pluripotency equivalent to that of embryonic stem cells. It has recently been shown by independent research including results from our laboratory that over-expression of a single gene, Oct3/4, in adult neural or mesenchymal stem cells also results in enhanced differentiation capacity including pluripotency. This development simplifies iPS generation and may reflect levels of endogenous expression of Sox2, Kfl4 and c-Myc in adult stem cells that are multipotent.

Also, since the Oct3/4 promoter has well-known response elements and transcription control mechanisms, re-programming based on environmental cues is now feasible through use of small molecular agents that selectively activate expression of Oct3/4. Our human MSCs expressing Oct3/4 allow further investigation of iPSC mechanisms.

Optimizing your hMSC Cultures:
1) Grow cells in 1 to 5% O2, 5% CO2, with the balance of the gas content as N2..
2) Use of our MSCGroTM media is highly recommended.
3) Subtrate-We recommend Greiner Bio-one TC-treated cell culture flasks or equivalent.

Source Organ

Human Stem Cell Collection

Citation Guide

When you publish your research, please cite our product as "AcceGen Biotech Cat.# XXX-0000". In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

For research use only

Product Type

Human Mesenchymal Stem Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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