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Human Cardiac Fibroblasts

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The cardiac fibroblasts (CF) are the principal cell type of the heart. They provide structural support for cardiac myocytes and are responsible for extracellular matrix synthesis in the heart during growth and pathophysiological conditions. CF are an important cellular component of myocardial responses to injury and the source of paracrine growth factors. Their proliferation and […]
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Home | Primary Cells | Human Primary Cells | Blood System Primary Cells | Human Cardiac Fibroblasts
Product Code

HCF
Species

Human
Cat.No

ABC-TC3533
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Cardiac Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Description

Human Cardiac Fibroblasts (HCFs) are isolated from the heart tissue, making up approximately 30% of the total cardiac cell population. As key regulators of myocardial structure and function, HCFs maintain tissue integrity by synthesizing and remodeling the extracellular matrix (ECM), including collagen, fibronectin, and elastin. HCFs proliferation plays a critical role in the development of cardiac fibrosis. HCFs display a spindle-shaped morphology and grow in an adherent monolayer under standard culture conditions.Studies have shown that stimuli such as inflammation and ischemia can lead to activation of cardiac fibroblasts and excessive deposition of ECM, which ultimately leads to the formation of cardiac fibrosis. Furthermore, emerging evidence suggests that activated HCFs can also secrete various pro-fibrotic cytokines and growth factors, such as TGF-β and CTGF, which further exacerbate fibrotic progression through autocrine and paracrine signaling mechanisms.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • Human Cardiac Fibroblasts (HCFs) can be used to study extracellular matrix producing and remodeling, as well as myocardial responses to injury like wounds, toxicology and pathology. Suitable to establish serum-free human feeder layers for human embryonic stem cell cultures.

Frequently Asked Questions

  • What are Human Cardiac Fibroblasts?

    Human Cardiac Fibroblasts are specialized cells found in the connective tissue of the heart. They play a crucial role in maintaining the structural integrity of the heart by producing and remodeling the extracellular matrix, which supports cardiac muscle cells and blood vessels.

  • What are the primary functions of Human Cardiac Fibroblasts?

    The primary functions of these fibroblasts include the synthesis and regulation of the extracellular matrix, which maintains the structure of the heart. They also play a critical role in the repair and remodeling of heart tissue following injury, such as myocardial infarction.

  • What are Human Cardiac Fibroblasts used for in research?

    Human Cardiac Fibroblasts are used in studies related to cardiac repair, fibrosis, heart failure, tissue engineering, and drug development. They are crucial in developing therapies that aim to prevent or reverse fibrosis and other pathological changes in the heart.

  • What factors influence the activation of Human Cardiac Fibroblasts?

    The activation of Human Cardiac Fibroblasts is influenced by factors like mechanical stress, inflammatory cytokines (e.g., TGF-β), and signals from injured cardiac tissue. These factors can lead to fibroblast-to-myofibroblast transformation, which contributes to the excessive production of extracellular matrix and fibrosis.

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