Human Cardiac Fibroblasts

Human Cardiac Fibroblasts (HCFs) are isolated from heart tissue, providing structural support for cardiac myocytes. HCF is one of the major cellular components in the heart, participating in heart function, homeostasis, and structure. Cardiac fibroblast cells secrete collagen and play a role in providing structural support for the heart. The cardiac fibroblast cell proliferation and synthesis of matrix are vital to scar formation in myocardial infarction and cardiac fibrosis. However, inappropriate cardiac fibroblast proliferation is a causative factor in cardiac fibrosis.
After heart injury, some chemical signals like growth factors, cytokines, and matrikines are secreted in paracrine or autocrine manner. Those factors act on cardiac fibroblasts via changing fibroblast gene expression and boosting cell migration to the injured area, which then promote wound healing and scar formation.
 
Why Choose HCF from AcceGen?
HCFs are in low passage for the best viability and plating efficiency and able to passage 15 passages under instructions.
Cardiac fibroblast cells are characterized by immunofluorescence with antibody specific to fibronectin.
Fibroblast specific media is optimized for HCF characteristics. Optimized Xeno-free media culturing cardiac fibroblast can be used to establish the model for would healing and other basic cell biology study. Optimized Xeno-free media are also available in AcceGen.