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Human Choroid Plexus Epithelial Cells

Product Name

Human Choroid Plexus Epithelial Cells

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Product Code

HCPEpiC

Cat.No

ABC-TC3568

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

The choroid plexus epithelial cells (CPEpiC) are the structural basis, form a selective barrier between the nervous system and the blood, and secrete cerebrospinal fluid into the ventricles of the brain. CPEpiC express inward-rectifying anion channels which are thought to have an important role in the secretion of cerebrospinal fluid. CPEpiC synthesize and secrete many growth factors and other peptides that are of trophic benefit following injury to regions of the cerebroventricular system. For example, several growth factors are upregulated in choroid plexus after ischemic and traumatic insults to the central nervous system. The presence of numerous types of growth factor receptors in choroid plexus allows growth factor mediation of recovery processes by autocrine and paracrine mechanisms. CPEpiC culture has been widely used to evaluate their morphological and physiological properties, and its capacity to serve as an in vitro model to access the cellular mechanisms of organic cation transport across the cerebrospinal fluid-blood barrier.HCPEpiC from AcceGen Research Laboratories are isolated from human choroid plexus. HCPEpiC are cryopreserved after purification and delivered frozen. Each vial contains >5×10^5 cells in 1 ml volume. HCPEpiC are characterized by immunofluorescent method with antibodies to cytokeratin-18, -19 and vimentin. HCPEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HCPEpiC are guaranteed to further expand for 5 population doublings in the conditions specified by AcceGen Research Laboratories.

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Erb, U., Schwerk, C., Schroten, H., & Karremann, M. (2020). Review of functional in vitro models of the blood-cerebrospinal fluid barrier in leukaemia research. Journal Of Neuroscience Methods, 329, 108478. https://doi.org/10.1016/j.jneumeth.2019.108478

Application

For research use only

Product Type

Nervous Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial
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