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Primary Cells

Human Gingival Fibroblasts

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Fibroblasts are mesenchymal cells with many vital functions during development and in adult organisms. They are responsible for much of the synthesis of extracellular matrix in connective tissues and play major roles in wound healing. Many diseases are associated with fibroblasts, either because fibroblasts are implicated in their etiology or because of the fibrosis that […]
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Home | Primary Cells | Human Primary Cells | Digestive System Primary Cells | Human Gingival Fibroblasts
Product Code

HGnF
Species

Human
Cat.No

ABC-TC3627
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Gingival
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Oral Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Description

Human Gingival Fibroblasts (HGFs) are isolated from healthy human gingival tissue. Morphologically, these cells are spindle-shaped or star-shaped and grow adherently when cultured in vitro. They are responsible for synthesizing extracellular matrix components such as collagen fibers and elastic fibers, and participate in the repair and regeneration of gingival tissue. HGFs also play a key role in sustaining inflammation response by interacting with pathogens and their component lipopolysaccharide (LPS) in periodontal disease [1-4]. Under inflammatory conditions, HGFs can secrete various cytokines and chemokines, such as IL-6 and IL-8, which amplify the immune response and contribute to periodontal tissue destruction. Additionally, their ability to modulate immune cell activity makes them crucial players in both wound healing and chronic inflammatory processes like periodontitis.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Duru Aras-Tosun, Canan Önder, Nihan Akdoğan, Şivge Kurgan, İrem Aktay, Erkan Tuncay, Kaan Orhan, “Astaxanthin Enhances Gingival Wound Healing following High Glucose-Induced Oxidative Stress”, BioMed Research International, vol. 2022, Article ID 4043105, 7 pages, 2022. https://doi.org/10.1155/2022/4043105

Application

  • Human Gingival Fibroblasts can be used as an in vitro cell model to study the pathogenesis of periodontal disease, especially to explore the molecular mechanism of fibroblast dysfunction in diseases such as gingival atrophy and periodontitis. These cells can also be used to construct bioactive scaffolds to promote the regeneration of gingival defects.

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