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Primary Cells

Human MS Peripheral Blood Mononuclear Cells

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Peripheral blood mononuclear cells are isolated from Multiple Sclerosis (MS) peripheral blood by diluting the whole blood with PBS and using gradient separation techniques. After centrifugation,the mononuclear cell layer is collected. Mononuclear Cells can be processed further to isolate subpopulations. Fresh MS PBMCs is available upon request.
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Home | Primary Cells | Human Primary Cells | PBMCs | Human MS Peripheral Blood Mononuclear Cells
Species

Human
Cat.No

ABC-TC3943
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Bone Marrow
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human Multiple Sclerosis (MS) Peripheral Blood Mononuclear Cells (PBMCs) are isolated from the peripheral blood of MS patients using density gradient centrifugation and mainly include T cells, B cells, NK cells, monocytes, and dendritic cells. These cells play a central role in MS pathogenesis by contributing to inflammation, antigen presentation, and immune dysregulation. MS PBMCs show altered subsets, such as increased CCR7+IL-6+ T cells and decreased T-bet^hiCD4+ T cells, along with mitochondrial dysfunction and oxidative stress. Th17 cells and γδ T cells secrete IL-17A, driving neuroinflammation and CNS infiltration. Additionally, MS PBMCs secrete high levels of proinflammatory cytokines like IFN-γ and IL-6, while monocytes release regulatory cytokines such as IL-10. These features contribute to disease progression and offer potential targets for therapeutic intervention and biomarker development. Fresh MS PBMCs are available upon request for research applications.

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Application

  • Human Multiple Sclerosis Peripheral Blood Mononuclear Cells are ideal for investigating the immunopathogenesis of MS and exploring immune cell subset dysfunction. These cells are commonly used in T cell polarization studies, cytokine profiling, and immune checkpoint analysis to assess the pro-inflammatory/anti-inflammatory balance in MS patients. Researchers utilize them to evaluate the function of Th1, Th17, Treg cells, and their interaction with monocytes or dendritic cells, mimicking the autoimmune environment. In addition, MS-PBMCs serve as an ex vivo model for testing immunomodulatory therapies or biologics targeting IL-17, IFN-γ, or TNF-α. Their clinical relevance also makes them suitable for biomarker discovery, genetic profiling, and drug screening to personalize MS treatment strategies.

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