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Primary Cells

Human Pulmonary Artery Adventitia Fibroblasts

  • For research use only

Cat No.

ABC-TC3773
Product Type

Pulmonary Cells
Cell Type

Fibroblast
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Pulmonary Artery
Disease

Normal
Storage

Liquid Nitrogen

Fibroblasts are mesenchymal cells which derived from the embryonic mesoderm.

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  • Human Pulmonary Artery Adventitia Fibroblasts
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Home | Primary Cells | Human Primary Cells | Respiratory System Primary Cells | Human Pulmonary Artery Adventitia Fibroblasts

Description

Human Pulmonary Artery Adventitial Fibroblasts are primary cells isolated from the adventitial (outermost) layer of human pulmonary arteries. These spindle-shaped cells exhibit characteristic fibroblastic morphology and strongly adhere to culture vessels, proliferating under standard conditions. They are preserved at early passages to maintain physiological phenotypes, indicating functional roles in redox signaling and extracellular matrix production. Under hypoxic or pathological stimuli, they secrete pro-angiogenic factors, thereby modulating neovascularization of the vasa vasorum and interacting with endothelial cells. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
Product Code

Human Pulmonary Artery Adventitia Fibroblasts, Pulmonary Adventitial Fibroblasts, PAAF Cells, Pulmonary Artery Fibroblasts
Species

Human
Cat.No

ABC-TC3773
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Pulmonary Artery
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Pulmonary Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Pulmonary Artery Adventitial Fibroblasts, also known as Human pulmonary artery adventitial fibroblasts (HPAAF), Primary lung artery adventitia cells, or human pulmonary stromal fibroblasts, are ideal for studies of pulmonary vascular remodeling, particularly in pulmonary hypertension, hypoxia-induced neovascularization, extracellular matrix deposition, redox-mediated signaling, and adventitial–endothelial crosstalk. They serve as a key cellular component in dissecting the fibrotic and inflammatory responses within the pulmonary arterial wall. They are valuable for testing anti-fibrotic therapies, angiogenesis inhibitors, and exploring fibroblast-driven vascular pathophysiology.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Davis-Hall D, Thomas E, Peña B, Magin CM. 3D-bioprinted, phototunable hydrogel models for studying adventitial fibroblast activation in pulmonary arterial hypertension. Biofabrication. 2022;15(1):10.1088/1758-5090/aca8cf. Published 2022 Dec 19. doi:10.1088/1758-5090/aca8cf

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